Nature's Timepiece-Molecular Coordination of Metabolism and Its Impact on Aging

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12310%2F13%3A43886437" target="_blank" >RIV/60076658:12310/13:43886437 - isvavai.cz</a>

Výsledek na webu

<a href="http://www.mdpi.com/1422-0067/14/2/3026" target="_blank" >http://www.mdpi.com/1422-0067/14/2/3026</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/ijms14023026" target="_blank" >10.3390/ijms14023026</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Nature's Timepiece-Molecular Coordination of Metabolism and Its Impact on Aging

Popis výsledku v původním jazyce

Circadian rhythms are found in almost all organisms from cyanobacteria to humans, where most behavioral and physiological processes occur over a period of approximately 24 h in tandem with the day/night cycles. In general, these rhythmic processes are under regulation of circadian clocks. The role of circadian clocks in regulating metabolism and consequently cellular and metabolic homeostasis is an intensively investigated area of research. However, the links between circadian clocks and aging are correlative and only recently being investigated. A physiological decline in most processes is associated with advancing age, and occurs at the onset of maturity and in some instances is the result of accumulation of cellular damage beyond a critical level. Afully functional circadian clock would be vital to timing events in general metabolism, thus contributing to metabolic health and to ensure an increased "health-span" during the process of aging. Here, we present recent evidence of links

Název v anglickém jazyce

Nature's Timepiece-Molecular Coordination of Metabolism and Its Impact on Aging

Popis výsledku anglicky

Circadian rhythms are found in almost all organisms from cyanobacteria to humans, where most behavioral and physiological processes occur over a period of approximately 24 h in tandem with the day/night cycles. In general, these rhythmic processes are under regulation of circadian clocks. The role of circadian clocks in regulating metabolism and consequently cellular and metabolic homeostasis is an intensively investigated area of research. However, the links between circadian clocks and aging are correlative and only recently being investigated. A physiological decline in most processes is associated with advancing age, and occurs at the onset of maturity and in some instances is the result of accumulation of cellular damage beyond a critical level. Afully functional circadian clock would be vital to timing events in general metabolism, thus contributing to metabolic health and to ensure an increased "health-span" during the process of aging. Here, we present recent evidence of links

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

ED - Fyziologie

OECD FORD obor

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Projekt

—

Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

ISSN

1422-0067

e-ISSN

—

Svazek periodika

14

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

24

Strana od-do

3026-3049

Kód UT WoS článku

000315397900045

EID výsledku v databázi Scopus

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