Nature?s timepiece ? molecular coordination of metabolism and impact on aging

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F13%3A00388970" target="_blank" >RIV/60077344:_____/13:00388970 - isvavai.cz</a>

Výsledek na webu

<a href="http://www.mdpi.com/1422-0067/14/2/3026" target="_blank" >http://www.mdpi.com/1422-0067/14/2/3026</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/ijms14023026" target="_blank" >10.3390/ijms14023026</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Nature?s timepiece ? molecular coordination of metabolism and impact on aging

Popis výsledku v původním jazyce

Circadian rhythms are found in almost all organisms from cyanobacteria to humans, where most behavioral and physiological processes occur over a period of approximately 24 h in tandem with the day/night cycles. The role of circadian clocks in regulatingmetabolism and consequently cellular and metabolic homeostasis is an intensively investigated area of research. A fully functional circadian clock would be vital to timing events in general metabolism, thus contributing to metabolic health and to ensurean increased ?health-span during the process of aging. Here, we present recent evidence of links between clocks, cellular metabolism, aging and oxidative stress. In the light of these data, we arrive at conceptual generalizations of this relationship across the spectrum of model organisms from fruit flies to mammals.

Název v anglickém jazyce

Nature?s timepiece ? molecular coordination of metabolism and impact on aging

Popis výsledku anglicky

Circadian rhythms are found in almost all organisms from cyanobacteria to humans, where most behavioral and physiological processes occur over a period of approximately 24 h in tandem with the day/night cycles. The role of circadian clocks in regulatingmetabolism and consequently cellular and metabolic homeostasis is an intensively investigated area of research. A fully functional circadian clock would be vital to timing events in general metabolism, thus contributing to metabolic health and to ensurean increased ?health-span during the process of aging. Here, we present recent evidence of links between clocks, cellular metabolism, aging and oxidative stress. In the light of these data, we arrive at conceptual generalizations of this relationship across the spectrum of model organisms from fruit flies to mammals.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

ED - Fyziologie

OECD FORD obor

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Projekt

<a href="/cs/project/GAP501%2F10%2F1215" target="_blank" >GAP501/10/1215: Stresové hormony a jejich potenciální využití v kontrole hmyzích populací</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

International Journal of Molecular Sciences

ISSN

1422-0067

e-ISSN

—

Svazek periodika

14

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

24

Strana od-do

3026-3049

Kód UT WoS článku

000315397900045

EID výsledku v databázi Scopus

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