The first cell-fate decision of mouse preimplantation embryo development: integrating cell position and polarity

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12310%2F17%3A43895653" target="_blank" >RIV/60076658:12310/17:43895653 - isvavai.cz</a>

Výsledek na webu

<a href="http://rsob.royalsocietypublishing.org/content/7/11/170210" target="_blank" >http://rsob.royalsocietypublishing.org/content/7/11/170210</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1098/rsob.170210" target="_blank" >10.1098/rsob.170210</a>

Jazyk výsledku

angličtina

Název v původním jazyce

The first cell-fate decision of mouse preimplantation embryo development: integrating cell position and polarity

Popis výsledku v původním jazyce

During the first cell-fate decision of mouse preimplantation embryo development, a population of outer-residing polar cells is segregated from a second population of inner apolar cells to form two distinct cell lineages: the trophectoderm and the inner cell mass (ICM), respectively. Historically, two models have been proposed to explain how the initial differences between these two cell populations originate and ultimately define them as the two stated early blastocyst stage cell lineages. The &apos;positional&apos; model proposes that cells acquire distinct fates based on differences in their relative position within the developing embryo, while the &apos;polarity&apos; model proposes that the differences driving the lineage segregation arise as a consequence of the differential inheritance of factors, which exhibit polarized subcellular localizations, upon asymmetric cell divisions. Although these two models have traditionally been considered separately, a growing body of evidence, collected over recent years, suggests the existence of a large degree of compatibility. Accordingly, the main aimof this reviewis to summarize the major historical and more contemporarily identified events that define the first cell-fate decision and to place them in the context of both the originally proposed positional and polarity models, thus highlighting their functional complementarity in describing distinct aspects of the developmental programme underpinning the first cell-fate decision in mouse embryogenesis.

Název v anglickém jazyce

The first cell-fate decision of mouse preimplantation embryo development: integrating cell position and polarity

Popis výsledku anglicky

During the first cell-fate decision of mouse preimplantation embryo development, a population of outer-residing polar cells is segregated from a second population of inner apolar cells to form two distinct cell lineages: the trophectoderm and the inner cell mass (ICM), respectively. Historically, two models have been proposed to explain how the initial differences between these two cell populations originate and ultimately define them as the two stated early blastocyst stage cell lineages. The &apos;positional&apos; model proposes that cells acquire distinct fates based on differences in their relative position within the developing embryo, while the &apos;polarity&apos; model proposes that the differences driving the lineage segregation arise as a consequence of the differential inheritance of factors, which exhibit polarized subcellular localizations, upon asymmetric cell divisions. Although these two models have traditionally been considered separately, a growing body of evidence, collected over recent years, suggests the existence of a large degree of compatibility. Accordingly, the main aimof this reviewis to summarize the major historical and more contemporarily identified events that define the first cell-fate decision and to place them in the context of both the originally proposed positional and polarity models, thus highlighting their functional complementarity in describing distinct aspects of the developmental programme underpinning the first cell-fate decision in mouse embryogenesis.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

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OECD FORD obor

10608 - Biochemistry and molecular biology

Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Open biology

ISSN

2046-2441

e-ISSN

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Svazek periodika

7

Číslo periodika v rámci svazku

11

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

14

Strana od-do

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Kód UT WoS článku

000416599600016

EID výsledku v databázi Scopus

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