How the intracellular partitioning of tRNA and tRNA modification enzymes affects mitochondrial function

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12310%2F18%3A43897634" target="_blank" >RIV/60076658:12310/18:43897634 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/60077344:_____/18:00498788

Výsledek na webu

<a href="https://iubmb.onlinelibrary.wiley.com/doi/epdf/10.1002/iub.1957" target="_blank" >https://iubmb.onlinelibrary.wiley.com/doi/epdf/10.1002/iub.1957</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/iub.1957" target="_blank" >10.1002/iub.1957</a>

Jazyk výsledku

angličtina

Název v původním jazyce

How the intracellular partitioning of tRNA and tRNA modification enzymes affects mitochondrial function

Popis výsledku v původním jazyce

Organisms have evolved different strategies to seclude certain molecules to specific locations of the cell. This is most pronounced in eukaryotes with their extensive intracellular membrane systems. Intracellular compartmentalization is particularly critical in genome containing organelles, which because of their bacterial evolutionary ancestry still maintain protein-synthesis machinery that resembles more their evolutionary origin than the extant eukaryotic cell they once joined as an endosymbiont. Despite this, it is clear that genome-containing organelles such as the mitochondria are not in isolation and many molecules make it across the mitochondrial membranes from the cytoplasm. In this realm the import of tRNAs and the enzymes that modify them prove most consequential. In this review, we discuss two recent examples of how modifications typically found in cytoplasmic tRNAs affect mitochondrial translation in organisms that forcibly import all their tRNAs from the cytoplasm. In our view, the combination of tRNA import and the compartmentalization of modification enzymes must have played a critical role in the evolution of the organelle. (c) 2018 IUBMB Life, 70(12):1207-1213, 2018

Název v anglickém jazyce

How the intracellular partitioning of tRNA and tRNA modification enzymes affects mitochondrial function

Popis výsledku anglicky

Organisms have evolved different strategies to seclude certain molecules to specific locations of the cell. This is most pronounced in eukaryotes with their extensive intracellular membrane systems. Intracellular compartmentalization is particularly critical in genome containing organelles, which because of their bacterial evolutionary ancestry still maintain protein-synthesis machinery that resembles more their evolutionary origin than the extant eukaryotic cell they once joined as an endosymbiont. Despite this, it is clear that genome-containing organelles such as the mitochondria are not in isolation and many molecules make it across the mitochondrial membranes from the cytoplasm. In this realm the import of tRNAs and the enzymes that modify them prove most consequential. In this review, we discuss two recent examples of how modifications typically found in cytoplasmic tRNAs affect mitochondrial translation in organisms that forcibly import all their tRNAs from the cytoplasm. In our view, the combination of tRNA import and the compartmentalization of modification enzymes must have played a critical role in the evolution of the organelle. (c) 2018 IUBMB Life, 70(12):1207-1213, 2018

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10608 - Biochemistry and molecular biology

Projekt

<a href="/cs/project/EF16_019%2F0000759" target="_blank" >EF16_019/0000759: Centrum výzkumu patogenity a virulence parazitů</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

IUBMB Life

ISSN

1521-6543

e-ISSN

—

Svazek periodika

70

Číslo periodika v rámci svazku

12

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

7

Strana od-do

1207-1213

Kód UT WoS článku

000450862000004

EID výsledku v databázi Scopus

2-s2.0-85055469254