Silver nanoparticles for solvent-free detection of small molecules and mass-to-charge calibration of laser desorption/ionization mass spectrometry

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12310%2F19%3A43899149" target="_blank" >RIV/60076658:12310/19:43899149 - isvavai.cz</a>

Výsledek na webu

<a href="https://sci-hub.tw/10.1116/1.5050878" target="_blank" >https://sci-hub.tw/10.1116/1.5050878</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1116/1.5050878" target="_blank" >10.1116/1.5050878</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Silver nanoparticles for solvent-free detection of small molecules and mass-to-charge calibration of laser desorption/ionization mass spectrometry

Popis výsledku v původním jazyce

This work aims at the utilization of nanostructured surfaces for advanced mass spectrometry [laser desorption/ionization mass spectrometry (LDI MS)]. The authors demonstrate that prepared nano-structures enable independent mass-to-charge calibration and also effectively substitute protonation agent for low-mass molecules instead of conventionally used matrices. Silver nanostructured surfaces were formed as homogeneous thin film, isolated nanoislands, and spherical nanoparticles. Besides the surface characterization, the paper focuses on the impact of LDI MS laser, irradiating the nanostructured surfaces, which results in the production of charged Ag clusters. Irradiated nanoparticle-based surfaces mostly provide single ionized species Ag+ while positive (Ag-n(+) ,n &lt;= 5) and negative ions (Ag-n(-), n &lt;= 7) were observed from the nanoislands film. It is shown that the ratio between particular ion line intensities can be tailored by the deposition time. The pattern of silver ions Ag-n (due to two natural isotopes) can be used for mass-to-charge calibration up to 1000 m/z. Additionally, the silver protonation improves the identification of small molecules. It is demonstrated on detection of sucrose (342.3 g/mol), fructose (180.2 g/mol), and creatinine (113.1 g/mol) molecules. Published by the AVS.

Název v anglickém jazyce

Silver nanoparticles for solvent-free detection of small molecules and mass-to-charge calibration of laser desorption/ionization mass spectrometry

Popis výsledku anglicky

This work aims at the utilization of nanostructured surfaces for advanced mass spectrometry [laser desorption/ionization mass spectrometry (LDI MS)]. The authors demonstrate that prepared nano-structures enable independent mass-to-charge calibration and also effectively substitute protonation agent for low-mass molecules instead of conventionally used matrices. Silver nanostructured surfaces were formed as homogeneous thin film, isolated nanoislands, and spherical nanoparticles. Besides the surface characterization, the paper focuses on the impact of LDI MS laser, irradiating the nanostructured surfaces, which results in the production of charged Ag clusters. Irradiated nanoparticle-based surfaces mostly provide single ionized species Ag+ while positive (Ag-n(+) ,n &lt;= 5) and negative ions (Ag-n(-), n &lt;= 7) were observed from the nanoislands film. It is shown that the ratio between particular ion line intensities can be tailored by the deposition time. The pattern of silver ions Ag-n (due to two natural isotopes) can be used for mass-to-charge calibration up to 1000 m/z. Additionally, the silver protonation improves the identification of small molecules. It is demonstrated on detection of sucrose (342.3 g/mol), fructose (180.2 g/mol), and creatinine (113.1 g/mol) molecules. Published by the AVS.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

21002 - Nano-processes (applications on nano-scale); (biomaterials to be 2.9)

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Vacuum Science and Technology B

ISSN

1071-1023

e-ISSN

—

Svazek periodika

37

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

7

Strana od-do

—

Kód UT WoS článku

000456825600025

EID výsledku v databázi Scopus

2-s2.0-85059817937