Novel BODIPY-subphthalocyanine dyads with reasonable photodynamic therapy behaviours

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12310%2F20%3A43901394" target="_blank" >RIV/60076658:12310/20:43901394 - isvavai.cz</a>

Výsledek na webu

<a href="https://pubs.rsc.org/en/content/articlelanding/2020/NJ/D0NJ02455D#!divAbstract" target="_blank" >https://pubs.rsc.org/en/content/articlelanding/2020/NJ/D0NJ02455D#!divAbstract</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1039/d0nj02455d" target="_blank" >10.1039/d0nj02455d</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Novel BODIPY-subphthalocyanine dyads with reasonable photodynamic therapy behaviours

Popis výsledku v původním jazyce

In this study, a set of bio-compatible and NIR emissive BODIPY-subphthalocyanine dyads (SP-DBD1-3) that contain amphiphilic triethyleneglycol units supporting partial water solubility and red absorbing BODIPY monomers (DBD1-3) were prepared. The photophysical and photochemical activities of these monomers, including fluorescence behaviors, singlet oxygen production, absorption, and emission profiles were investigated. The effect of the presence of halogen atoms and the BODIPY unit in dyads on the ability of generating singlet oxygen was evaluated. BODIPY-subphthalocyanine dyads showed two absorption bands at about 550 nm and 650 nm and high singlet oxygen quantum yields (up to 91%) at room temperature. The weaker fluorescence emissions, shorter fluorescence lifetimes but better singlet oxygen production capacities of dyads compared to those of BODIPY monomers have been explainedviathe energy transfer process from the donor subphthalocyanine unit to the acceptor BODIPY part, supporting ISC. Also,in vitrostudies underlined that the novel compounds (DBD1,DBD2,SP-DBD-2, andSP-DBD3) were successful in terms of the induction of cell death under red light; however, they did not affect the cells in dark, indicating these compounds as agents that can be used in photodynamic therapyin vivoin further studies.

Název v anglickém jazyce

Novel BODIPY-subphthalocyanine dyads with reasonable photodynamic therapy behaviours

Popis výsledku anglicky

In this study, a set of bio-compatible and NIR emissive BODIPY-subphthalocyanine dyads (SP-DBD1-3) that contain amphiphilic triethyleneglycol units supporting partial water solubility and red absorbing BODIPY monomers (DBD1-3) were prepared. The photophysical and photochemical activities of these monomers, including fluorescence behaviors, singlet oxygen production, absorption, and emission profiles were investigated. The effect of the presence of halogen atoms and the BODIPY unit in dyads on the ability of generating singlet oxygen was evaluated. BODIPY-subphthalocyanine dyads showed two absorption bands at about 550 nm and 650 nm and high singlet oxygen quantum yields (up to 91%) at room temperature. The weaker fluorescence emissions, shorter fluorescence lifetimes but better singlet oxygen production capacities of dyads compared to those of BODIPY monomers have been explainedviathe energy transfer process from the donor subphthalocyanine unit to the acceptor BODIPY part, supporting ISC. Also,in vitrostudies underlined that the novel compounds (DBD1,DBD2,SP-DBD-2, andSP-DBD3) were successful in terms of the induction of cell death under red light; however, they did not affect the cells in dark, indicating these compounds as agents that can be used in photodynamic therapyin vivoin further studies.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10403 - Physical chemistry

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

New Journal of Chemistry

ISSN

1144-0546

e-ISSN

—

Svazek periodika

44

Číslo periodika v rámci svazku

32

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

7

Strana od-do

13738-13744

Kód UT WoS článku

000560486100026

EID výsledku v databázi Scopus

2-s2.0-85090110866