Hepatic Ethoxy-, Methoxy- and Pentoxyresorufin O-Dealkylase Activities in Landrace and Duroc Pigs Stimulated with hCG

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12520%2F10%3A00011451" target="_blank" >RIV/60076658:12520/10:00011451 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Hepatic Ethoxy-, Methoxy- and Pentoxyresorufin O-Dealkylase Activities in Landrace and Duroc Pigs Stimulated with hCG

Popis výsledku v původním jazyce

The effect of human chorionic gonadotropin (hCG) stimulation on the activities of ethoxyresorufin O-deethylase (EROD), methoxyresorufin O-demethylase (MROD) and pentoxyresorufin O-depentylase (PROD) was studied in intact male pigs of purebred Landrace and Duroc breeds. We found that EROD activity was suppressed by hCG-stimulation in Landrace (p = 0.004), but not Duroc pigs (p > 0.05). Generally, EROD activity was higher in Duroc pigs compared with Landrace (p = 0.017). Methoxyresorufin O-demethylase andPROD activities did not differ between groups (p > 0.05). To further characterize EROD, MROD and PROD, enzyme kinetic studies were performed. Vmax values for EROD and MROD in both breeds were lower after hCG stimuation (p < 0.001 Landrace; p < 0.05 Duroc). Additionally, Vmax values for EROD significantly differed, being higher in Duroc pigs (p < 0.05). We concluded that both hCG stimulation and breed differences may be important in the regulativ of EROD and MROD activities.

Název v anglickém jazyce

Hepatic Ethoxy-, Methoxy- and Pentoxyresorufin O-Dealkylase Activities in Landrace and Duroc Pigs Stimulated with hCG

Popis výsledku anglicky

The effect of human chorionic gonadotropin (hCG) stimulation on the activities of ethoxyresorufin O-deethylase (EROD), methoxyresorufin O-demethylase (MROD) and pentoxyresorufin O-depentylase (PROD) was studied in intact male pigs of purebred Landrace and Duroc breeds. We found that EROD activity was suppressed by hCG-stimulation in Landrace (p = 0.004), but not Duroc pigs (p > 0.05). Generally, EROD activity was higher in Duroc pigs compared with Landrace (p = 0.017). Methoxyresorufin O-demethylase andPROD activities did not differ between groups (p > 0.05). To further characterize EROD, MROD and PROD, enzyme kinetic studies were performed. Vmax values for EROD and MROD in both breeds were lower after hCG stimuation (p < 0.001 Landrace; p < 0.05 Duroc). Additionally, Vmax values for EROD significantly differed, being higher in Duroc pigs (p < 0.05). We concluded that both hCG stimulation and breed differences may be important in the regulativ of EROD and MROD activities.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

GL - Rybářství

OECD FORD obor

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Projekt

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Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2010

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Reproduction in Domestic Animals

ISSN

0936-6768

e-ISSN

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Svazek periodika

45

Číslo periodika v rámci svazku

6

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

6

Strana od-do

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Kód UT WoS článku

000284429900006

EID výsledku v databázi Scopus

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