Modulations in androgen and estrogen mediating genes and testicular response in male goldfish exposed to bisphenol A

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12520%2F12%3A43883450" target="_blank" >RIV/60076658:12520/12:43883450 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1002/etc.1919" target="_blank" >http://dx.doi.org/10.1002/etc.1919</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/etc.1919" target="_blank" >10.1002/etc.1919</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Modulations in androgen and estrogen mediating genes and testicular response in male goldfish exposed to bisphenol A

Popis výsledku v původním jazyce

Adverse effects of bisphenol A (BPA) on reproductive physiology were studied in male goldfish (Carassius auratus) exposed to nominal environmentally relevant concentrations (0.2 and 20?mu g/L) for up to 90 d. Transcriptions of various reproductive geneswere measured in brain, liver, and testis to investigate the BPA modes of action. Volume, density, total number, motility, and velocity of sperm were measured to assess testicular function. At 0.2?mu g/L, BPA reduced steroidogenetic acute regulatory protein and increased estrogen receptors (ERs) messenger RNA (mRNA) transcript (ER beta 1 in liver and ER beta 2 in testis) after 90 d. At 20?mu g/L, BPA increased mRNA transcript of androgen receptor in testis, brain- and testis-specific aromatase, and vitellogenin in liver after 90, 30, 60, and 60 d, respectively. Transcripts of ERs mRNA were increased after 30 to 60 d at 20?mu g/L BPA; increase in ER beta 1 mRNA was observed in testis after 7 d. Total number, volume, and motility of sperm

Název v anglickém jazyce

Modulations in androgen and estrogen mediating genes and testicular response in male goldfish exposed to bisphenol A

Popis výsledku anglicky

Adverse effects of bisphenol A (BPA) on reproductive physiology were studied in male goldfish (Carassius auratus) exposed to nominal environmentally relevant concentrations (0.2 and 20?mu g/L) for up to 90 d. Transcriptions of various reproductive geneswere measured in brain, liver, and testis to investigate the BPA modes of action. Volume, density, total number, motility, and velocity of sperm were measured to assess testicular function. At 0.2?mu g/L, BPA reduced steroidogenetic acute regulatory protein and increased estrogen receptors (ERs) messenger RNA (mRNA) transcript (ER beta 1 in liver and ER beta 2 in testis) after 90 d. At 20?mu g/L, BPA increased mRNA transcript of androgen receptor in testis, brain- and testis-specific aromatase, and vitellogenin in liver after 90, 30, 60, and 60 d, respectively. Transcripts of ERs mRNA were increased after 30 to 60 d at 20?mu g/L BPA; increase in ER beta 1 mRNA was observed in testis after 7 d. Total number, volume, and motility of sperm

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

GL - Rybářství

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Environmental toxicology and chemistry

ISSN

0730-7268

e-ISSN

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Svazek periodika

31

Číslo periodika v rámci svazku

9

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

9

Strana od-do

2069-2077

Kód UT WoS článku

000307938500020

EID výsledku v databázi Scopus

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