Effects of waterborne cadmium on thyroid hormone levels and related gene expression in Chinese rare minnow larvae

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12520%2F14%3A43886816" target="_blank" >RIV/60076658:12520/14:43886816 - isvavai.cz</a>

Výsledek na webu

<a href="http://www.sciencedirect.com/science/article/pii/S1532045614000106" target="_blank" >http://www.sciencedirect.com/science/article/pii/S1532045614000106</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.cbpc.2014.02.001" target="_blank" >10.1016/j.cbpc.2014.02.001</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Effects of waterborne cadmium on thyroid hormone levels and related gene expression in Chinese rare minnow larvae

Popis výsledku v původním jazyce

Cadmium is a heavy metal abundant in the environment that can induce endocrine disorder and toxicity in aquatic organisms at low levels. However, its effects on the thyroid system in fish are still unclear. In this study, the thyroid hormone (TH) levelsand the expression profiles of genes related to hypothalamic-pituitary-thyroid (HPT) axis, including corticotropin-releasing hormone (crh), thyroid stimulating hormone beta (tsh beta), solute carrier family 5 (sodium iodide symporter) member 5 (slc5a5),thyroglobulin (tg), thyroid hormone receptor alpha (tr alpha) and thyroid hormone receptor beta (tr beta), were determined in whole body of Chinese rare minnow (Gobiogpris rams) larvae after exposure to different levels of Cd2+ (0, 0.5 and 2.5 mg/L) for4 days. And the 96-h lethal concentration of Cd2+ on rare minnow larvae was determined as 2.59 mg/L. The results showed that crh, slc5a5, tg and tsh beta mRNA levels were significantly up-regulated in the larvae, but the gene expression o

Název v anglickém jazyce

Effects of waterborne cadmium on thyroid hormone levels and related gene expression in Chinese rare minnow larvae

Popis výsledku anglicky

Cadmium is a heavy metal abundant in the environment that can induce endocrine disorder and toxicity in aquatic organisms at low levels. However, its effects on the thyroid system in fish are still unclear. In this study, the thyroid hormone (TH) levelsand the expression profiles of genes related to hypothalamic-pituitary-thyroid (HPT) axis, including corticotropin-releasing hormone (crh), thyroid stimulating hormone beta (tsh beta), solute carrier family 5 (sodium iodide symporter) member 5 (slc5a5),thyroglobulin (tg), thyroid hormone receptor alpha (tr alpha) and thyroid hormone receptor beta (tr beta), were determined in whole body of Chinese rare minnow (Gobiogpris rams) larvae after exposure to different levels of Cd2+ (0, 0.5 and 2.5 mg/L) for4 days. And the 96-h lethal concentration of Cd2+ on rare minnow larvae was determined as 2.59 mg/L. The results showed that crh, slc5a5, tg and tsh beta mRNA levels were significantly up-regulated in the larvae, but the gene expression o

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

GL - Rybářství

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Comparative Biochemistry and Physiology C - Toxicology and Pharmacology

ISSN

1532-0456

e-ISSN

—

Svazek periodika

161

Číslo periodika v rámci svazku

April

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

5

Strana od-do

53-57

Kód UT WoS článku

000333792400008

EID výsledku v databázi Scopus

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