Alteration of thyroid hormone levels and related gene expression in Chinese rare minnow larvae exposed to mercury chloride

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12520%2F14%3A43886815" target="_blank" >RIV/60076658:12520/14:43886815 - isvavai.cz</a>

Výsledek na webu

<a href="http://www.sciencedirect.com/science/article/pii/S1382668914001562" target="_blank" >http://www.sciencedirect.com/science/article/pii/S1382668914001562</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.etap.2014.07.002" target="_blank" >10.1016/j.etap.2014.07.002</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Alteration of thyroid hormone levels and related gene expression in Chinese rare minnow larvae exposed to mercury chloride

Popis výsledku v původním jazyce

Mercury is a prominent environmental contaminant that causes endocrine disorder to human and other organisms. But little is known about the response of the thyroid functions and hypothalamic-pituitary-thyroid (HPT) axis to mercury in teleosts and the fewstudies that are available have not yielded consistent results. In this study, expression profiles of corticotropin-releasing hormone (crh), thyroid stimulating hormone beta (tsh beta), solute carrier family 5 (sodium iodide symporter) member 5 (slc5a5), thyroglobulin (tg), thyroid hormone receptor alpha (tr alpha) and thyroid hormone receptor beta (tr beta) genes were determined in whole-body of Chinese rare minnow (Gobiocypris Torus) larvae after exposure to different levels of Hg2+ (0, 0.1 and 0.3 mg/l) for 4 days, as well as the thyroid hormones (THs) levels. Moreover, the 96-h lethal concentration of Hg2+ on rare minnow larvae was determined as 0.32 mg/l. The results showed that crh, tg, tr alpha and tr beta mRNA levels were signi

Název v anglickém jazyce

Alteration of thyroid hormone levels and related gene expression in Chinese rare minnow larvae exposed to mercury chloride

Popis výsledku anglicky

Mercury is a prominent environmental contaminant that causes endocrine disorder to human and other organisms. But little is known about the response of the thyroid functions and hypothalamic-pituitary-thyroid (HPT) axis to mercury in teleosts and the fewstudies that are available have not yielded consistent results. In this study, expression profiles of corticotropin-releasing hormone (crh), thyroid stimulating hormone beta (tsh beta), solute carrier family 5 (sodium iodide symporter) member 5 (slc5a5), thyroglobulin (tg), thyroid hormone receptor alpha (tr alpha) and thyroid hormone receptor beta (tr beta) genes were determined in whole-body of Chinese rare minnow (Gobiocypris Torus) larvae after exposure to different levels of Hg2+ (0, 0.1 and 0.3 mg/l) for 4 days, as well as the thyroid hormones (THs) levels. Moreover, the 96-h lethal concentration of Hg2+ on rare minnow larvae was determined as 0.32 mg/l. The results showed that crh, tg, tr alpha and tr beta mRNA levels were signi

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

GL - Rybářství

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Environmental Toxicology and Pharmacology

ISSN

1382-6689

e-ISSN

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Svazek periodika

38

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

7

Strana od-do

325-331

Kód UT WoS článku

000341468900036

EID výsledku v databázi Scopus

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