Alteration of Antioxidant Response and Expression of Related Genes by Cadmium in Chinese Rare Minnow Larvae

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12520%2F15%3A43888549" target="_blank" >RIV/60076658:12520/15:43888549 - isvavai.cz</a>

Výsledek na webu

<a href="http://onlinelibrary.wiley.com/doi/10.1002/clen.201400113/abstract" target="_blank" >http://onlinelibrary.wiley.com/doi/10.1002/clen.201400113/abstract</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/clen.201400113" target="_blank" >10.1002/clen.201400113</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Alteration of Antioxidant Response and Expression of Related Genes by Cadmium in Chinese Rare Minnow Larvae

Popis výsledku v původním jazyce

In the present study, antioxidant parameters were measured in whole body of Chinese rare minnow larvae (Gobiocypris rarus) after exposure to Cd2+ (0, 0.5, and 2.5 mg/L) for four days, as well as a series of genes expression, including cortisol receptor(cr), Na+/K+-ATPase (aptase), and prolactin (prl) genes involved in ion-regulatory process, insulin-like growth factor I (igf1) and growth hormone (gh) related to growth rate, as well as heat shock protein 70(hsp70) and metallothionein(mt) used as physiological stress indices. The results showed that oxidative stress was generated in fish exposed to Cd2+ and the transcription of the cr, atpase, gh, hsp70, and mt genes increased in a dose-dependent manner, but two genes expressions, prl and igf1, showed adecrease in the treated groups. The changes in antioxidant responses and the altered genes expression in this study could provide useful information for evaluating the influence mechanisms of cadmium on fish, and could be used as potentia

Název v anglickém jazyce

Alteration of Antioxidant Response and Expression of Related Genes by Cadmium in Chinese Rare Minnow Larvae

Popis výsledku anglicky

In the present study, antioxidant parameters were measured in whole body of Chinese rare minnow larvae (Gobiocypris rarus) after exposure to Cd2+ (0, 0.5, and 2.5 mg/L) for four days, as well as a series of genes expression, including cortisol receptor(cr), Na+/K+-ATPase (aptase), and prolactin (prl) genes involved in ion-regulatory process, insulin-like growth factor I (igf1) and growth hormone (gh) related to growth rate, as well as heat shock protein 70(hsp70) and metallothionein(mt) used as physiological stress indices. The results showed that oxidative stress was generated in fish exposed to Cd2+ and the transcription of the cr, atpase, gh, hsp70, and mt genes increased in a dose-dependent manner, but two genes expressions, prl and igf1, showed adecrease in the treated groups. The changes in antioxidant responses and the altered genes expression in this study could provide useful information for evaluating the influence mechanisms of cadmium on fish, and could be used as potentia

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

DN - Vliv životního prostředí na zdraví

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Clean - Soil, Air, Water

ISSN

1863-0650

e-ISSN

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Svazek periodika

43

Číslo periodika v rámci svazku

5

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

5

Strana od-do

671-675

Kód UT WoS článku

000354626200006

EID výsledku v databázi Scopus

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