Efficacy of poly (lactic-co-glycolic acid) microparticles as a gonadotropin-releasing hormone analogue delivery system to stimulate ovulation of peled Coregonus peled

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12520%2F21%3A43902710" target="_blank" >RIV/60076658:12520/21:43902710 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14160/21:00119766

Výsledek na webu

<a href="https://doi.org/10.17221/57/2021-CJAS" target="_blank" >https://doi.org/10.17221/57/2021-CJAS</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.17221/57/2021-CJAS" target="_blank" >10.17221/57/2021-CJAS</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Efficacy of poly (lactic-co-glycolic acid) microparticles as a gonadotropin-releasing hormone analogue delivery system to stimulate ovulation of peled Coregonus peled

Popis výsledku v původním jazyce

The aim of the study was to determine the efficacy of poly (lactic-co-glycolic acid) microparticles as a carrier of gonadotropin-relea sing hormone analogues (GnRHa) for induction of ovulation in peled Coregonus peled. Female peled were injected intraperitoneally with 1) saline solution only (control), 2) mammalian GnRHa at 25 vg/kg body weight, 3) GnRHa in 753-type microparticles at 50 vg/kg, or 4) GnRHa in 653-type microparticles at 50 vg/kg. Blood plasma samples were taken on days 0, 4, 8, and 12 post-injection. All hormone treatments induced synchronous ovulation and higher cumulative ovulation compared to controls. Hormone treatments did not affect relative fecundity or the percentage of eyed eggs. Testosterone level decreased toward the onset of ovulation. On day eight of the trial, the testosterone level was significantly lower in hormone-treated groups compared to the control group. The level of 17P-oestradiol showed a decreasing trend post-injection, with the lowest observed level on day eight. Our results demonstrate that ovulation can be induced in the peled by the sustained - release of GnRHa in poly (lactic-co-glycolic acid) microparticles, but the treatment does not improve reproductive performance.

Název v anglickém jazyce

Efficacy of poly (lactic-co-glycolic acid) microparticles as a gonadotropin-releasing hormone analogue delivery system to stimulate ovulation of peled Coregonus peled

Popis výsledku anglicky

The aim of the study was to determine the efficacy of poly (lactic-co-glycolic acid) microparticles as a carrier of gonadotropin-relea sing hormone analogues (GnRHa) for induction of ovulation in peled Coregonus peled. Female peled were injected intraperitoneally with 1) saline solution only (control), 2) mammalian GnRHa at 25 vg/kg body weight, 3) GnRHa in 753-type microparticles at 50 vg/kg, or 4) GnRHa in 653-type microparticles at 50 vg/kg. Blood plasma samples were taken on days 0, 4, 8, and 12 post-injection. All hormone treatments induced synchronous ovulation and higher cumulative ovulation compared to controls. Hormone treatments did not affect relative fecundity or the percentage of eyed eggs. Testosterone level decreased toward the onset of ovulation. On day eight of the trial, the testosterone level was significantly lower in hormone-treated groups compared to the control group. The level of 17P-oestradiol showed a decreasing trend post-injection, with the lowest observed level on day eight. Our results demonstrate that ovulation can be induced in the peled by the sustained - release of GnRHa in poly (lactic-co-glycolic acid) microparticles, but the treatment does not improve reproductive performance.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

40103 - Fishery

Projekt

<a href="/cs/project/QK1810221" target="_blank" >QK1810221: Využití mikročástic jako nosičů hormonálně aktivních látek v řízené reprodukci ryb.</a><br>

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Czech Journal of Animal Science : Živočišná výroba

ISSN

1212-1819

e-ISSN

—

Svazek periodika

66

Číslo periodika v rámci svazku

8

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

8

Strana od-do

331-338

Kód UT WoS článku

000680010100005

EID výsledku v databázi Scopus

2-s2.0-85112543198