Determination of the relationship between class IV sirtuin genes and growth traits in Chinese black Tibetan sheep

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12520%2F23%3A43906590" target="_blank" >RIV/60076658:12520/23:43906590 - isvavai.cz</a>

Výsledek na webu

<a href="https://doi.org/10.1080/10495398.2021.2016434" target="_blank" >https://doi.org/10.1080/10495398.2021.2016434</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1080/10495398.2021.2016434" target="_blank" >10.1080/10495398.2021.2016434</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Determination of the relationship between class IV sirtuin genes and growth traits in Chinese black Tibetan sheep

Popis výsledku v původním jazyce

Class IV sirtuin (SIRT6 and SIRT7) played essential roles in biometabolism processes via deacetylating specific transcription factors. The present study was conducted to search for mutations in SIRT6/7 and determine their associations with growth traits in black Tibetan sheep. Via DNA sequencing methods, three single-nucleotide polymorphisms (SNPs) were identified in 427 ewes, including a mutation (g.3724C &gt; T) in the intron 1 of SIRT6 and two mutations (g.3668G &gt; T and g.4223C &gt; G) in SIRT7 intron 6 and 8, respectively. Based on the chi(2) test, both g.3724C &gt; T and g.4223C &gt; G loci fitted with Hardy-Weinberg equilibrium (p &gt; 0.05). Compared with animals with genotype TT, the CC genotype at g.3724C &gt; T locus (SIRT6) exhibited the highest mean for body weight (p &lt; 0.05) and heart girth (p &lt; 0.05). At g.3668G &gt; T locus (SIRT7), individuals carrying the GG genotype tended to have heavier body weight than those of TT genotype (p &lt; 0.05). With the exception of body weight, body measurement traits not affected by combinative genotype (p &gt; 0.05). Our results could be used as genetic markers for marker-assisted selection and maybe guide sheep breeding in economic traits.

Název v anglickém jazyce

Determination of the relationship between class IV sirtuin genes and growth traits in Chinese black Tibetan sheep

Popis výsledku anglicky

Class IV sirtuin (SIRT6 and SIRT7) played essential roles in biometabolism processes via deacetylating specific transcription factors. The present study was conducted to search for mutations in SIRT6/7 and determine their associations with growth traits in black Tibetan sheep. Via DNA sequencing methods, three single-nucleotide polymorphisms (SNPs) were identified in 427 ewes, including a mutation (g.3724C &gt; T) in the intron 1 of SIRT6 and two mutations (g.3668G &gt; T and g.4223C &gt; G) in SIRT7 intron 6 and 8, respectively. Based on the chi(2) test, both g.3724C &gt; T and g.4223C &gt; G loci fitted with Hardy-Weinberg equilibrium (p &gt; 0.05). Compared with animals with genotype TT, the CC genotype at g.3724C &gt; T locus (SIRT6) exhibited the highest mean for body weight (p &lt; 0.05) and heart girth (p &lt; 0.05). At g.3668G &gt; T locus (SIRT7), individuals carrying the GG genotype tended to have heavier body weight than those of TT genotype (p &lt; 0.05). With the exception of body weight, body measurement traits not affected by combinative genotype (p &gt; 0.05). Our results could be used as genetic markers for marker-assisted selection and maybe guide sheep breeding in economic traits.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

40201 - Animal and dairy science; (Animal biotechnology to be 4.4)

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Animal Biotechnology

ISSN

1049-5398

e-ISSN

1532-2378

Svazek periodika

34

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

7

Strana od-do

1232-1238

Kód UT WoS článku

000731246100001

EID výsledku v databázi Scopus

2-s2.0-85121692366