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Polymorphism of the PLIN1 gene and its association with body measures and ultrasound carcass traits in Qinchuan beef cattle

Identifikátory výsledku

  • Kód výsledku v IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12520%2F20%3A43901033" target="_blank" >RIV/60076658:12520/20:43901033 - isvavai.cz</a>

  • Výsledek na webu

    <a href="https://doi.org/10.1139/gen-2019-0184" target="_blank" >https://doi.org/10.1139/gen-2019-0184</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1139/gen-2019-0184" target="_blank" >10.1139/gen-2019-0184</a>

Alternativní jazyky

  • Jazyk výsledku

    angličtina

  • Název v původním jazyce

    Polymorphism of the PLIN1 gene and its association with body measures and ultrasound carcass traits in Qinchuan beef cattle

  • Popis výsledku v původním jazyce

    The PLIN1 gene produces a phosphorylated protein wrapped in lipid droplets in adipocytes. This phosphorylation assists the mobilization of fat into adipose tissue. The purpose of the experiment was to study the polymorphism of the PLIN1 gene and its relationship with the body and carcass characteristics of Qinchuan cattle to find molecular genetic markers that can be used for breeding. The expression level of the PLIN1 gene was determined in various tissues by qRT-PCR. The results showed that the highest level of PLN1 expression was found in subcutaneous fat, followed by the heart and longissimus muscle, and the lowest level was found in the kidney. Five SNP loci of the PLIN1 gene were identified in 510 Qinchuan cattle, including g.3580T&gt;C (SNP1), g.3898G&gt;A (SNP2), g.8333G&gt;A (SNP3), g.10517T&gt;C (SNP4), and g.10538G&gt;T (SNP5). The results show that SNP1, SNP2, SNP3, and SNP4 were moderately polymorphic (0.25 &lt; PIC &lt; 0.5), while SNP5 was minimally polymorphic (PIC &lt; 0.25). SNP2, SNP3, and SNP5 were within Hardy-Weinberg equilibrium (P &gt; 0.05), but SNP1 and SNP4 were not (P &lt; 0.05). Correlation analysis showed that the five SNPs of the PLIN1 gene were correlated with back-fat depth, intramuscular fat, and chest depth of Qinchuan cattle. The double haplotype H2H4 in Qinchuan beef was associated with body and carcass traits. We conclude that variants mapped within PLIN1 can be used in marker-assisted selection for carcass quality and body traits in breed improvement programs for Qinchuan cattle.

  • Název v anglickém jazyce

    Polymorphism of the PLIN1 gene and its association with body measures and ultrasound carcass traits in Qinchuan beef cattle

  • Popis výsledku anglicky

    The PLIN1 gene produces a phosphorylated protein wrapped in lipid droplets in adipocytes. This phosphorylation assists the mobilization of fat into adipose tissue. The purpose of the experiment was to study the polymorphism of the PLIN1 gene and its relationship with the body and carcass characteristics of Qinchuan cattle to find molecular genetic markers that can be used for breeding. The expression level of the PLIN1 gene was determined in various tissues by qRT-PCR. The results showed that the highest level of PLN1 expression was found in subcutaneous fat, followed by the heart and longissimus muscle, and the lowest level was found in the kidney. Five SNP loci of the PLIN1 gene were identified in 510 Qinchuan cattle, including g.3580T&gt;C (SNP1), g.3898G&gt;A (SNP2), g.8333G&gt;A (SNP3), g.10517T&gt;C (SNP4), and g.10538G&gt;T (SNP5). The results show that SNP1, SNP2, SNP3, and SNP4 were moderately polymorphic (0.25 &lt; PIC &lt; 0.5), while SNP5 was minimally polymorphic (PIC &lt; 0.25). SNP2, SNP3, and SNP5 were within Hardy-Weinberg equilibrium (P &gt; 0.05), but SNP1 and SNP4 were not (P &lt; 0.05). Correlation analysis showed that the five SNPs of the PLIN1 gene were correlated with back-fat depth, intramuscular fat, and chest depth of Qinchuan cattle. The double haplotype H2H4 in Qinchuan beef was associated with body and carcass traits. We conclude that variants mapped within PLIN1 can be used in marker-assisted selection for carcass quality and body traits in breed improvement programs for Qinchuan cattle.

Klasifikace

  • Druh

    J<sub>imp</sub> - Článek v periodiku v databázi Web of Science

  • CEP obor

  • OECD FORD obor

    10603 - Genetics and heredity (medical genetics to be 3)

Návaznosti výsledku

  • Projekt

    <a href="/cs/project/LM2018099" target="_blank" >LM2018099: Jihočeské výzkumné centrum akvakultury a biodiverzity hydrocenóz</a><br>

  • Návaznosti

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Ostatní

  • Rok uplatnění

    2020

  • Kód důvěrnosti údajů

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Údaje specifické pro druh výsledku

  • Název periodika

    Genome

  • ISSN

    0831-2796

  • e-ISSN

  • Svazek periodika

    63

  • Číslo periodika v rámci svazku

    10

  • Stát vydavatele periodika

    CA - Kanada

  • Počet stran výsledku

    10

  • Strana od-do

    483-492

  • Kód UT WoS článku

    000576781000002

  • EID výsledku v databázi Scopus

    2-s2.0-85091974975