Acquisition of neural crest promoted thyroid evolution from chordate endostyle

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12520%2F25%3A43910047" target="_blank" >RIV/60076658:12520/25:43910047 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11310/25:10500906

Výsledek na webu

<a href="https://www.science.org/doi/full/10.1126/sciadv.adv2657" target="_blank" >https://www.science.org/doi/full/10.1126/sciadv.adv2657</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1126/sciadv.adv2657" target="_blank" >10.1126/sciadv.adv2657</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Acquisition of neural crest promoted thyroid evolution from chordate endostyle

Popis výsledku v původním jazyce

The endostyle is an endodermal organ unique to nonvertebrate chordates except for lamprey larvae, where it serves as forerunner to the adult thyroid. Here, we examine whether the acquisition of neural crest in the vertebrate lineage played a role in the elaboration of the endostyle. CM-DiI lineage tracing reveals a neural crest contribution to the endostyle, and CRISPR-Cas9 mutagenesis of key neural crest genes causes endostyle defects including formation of a single rather than bilobed structure. RNA sequencing reveals gene profiles characteristic of embryonic neural crest cells and Schwann cell precursors in the developing endostyle. Contrasting with the prevailing view that the endostyle is an endoderm-derived organ, we propose that the acquisition of the neural crest played a critical step in promoting thyroid evolution from chordate endostyle.

Název v anglickém jazyce

Acquisition of neural crest promoted thyroid evolution from chordate endostyle

Popis výsledku anglicky

The endostyle is an endodermal organ unique to nonvertebrate chordates except for lamprey larvae, where it serves as forerunner to the adult thyroid. Here, we examine whether the acquisition of neural crest in the vertebrate lineage played a role in the elaboration of the endostyle. CM-DiI lineage tracing reveals a neural crest contribution to the endostyle, and CRISPR-Cas9 mutagenesis of key neural crest genes causes endostyle defects including formation of a single rather than bilobed structure. RNA sequencing reveals gene profiles characteristic of embryonic neural crest cells and Schwann cell precursors in the developing endostyle. Contrasting with the prevailing view that the endostyle is an endoderm-derived organ, we propose that the acquisition of the neural crest played a critical step in promoting thyroid evolution from chordate endostyle.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10605 - Developmental biology

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Science Advances

ISSN

2375-2548

e-ISSN

2375-2548

Svazek periodika

11

Číslo periodika v rámci svazku

32

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

10

Strana od-do

nestránkováno

Kód UT WoS článku

001545562900013

EID výsledku v databázi Scopus

2-s2.0-105013075655