Evaluation of targeted and high-resolution mass spectrometry methods for environmental monitoring of pharmaceuticals

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12520%2F25%3A43910055" target="_blank" >RIV/60076658:12520/25:43910055 - isvavai.cz</a>

Výsledek na webu

<a href="https://doi.org/10.1016/j.mex.2025.103666" target="_blank" >https://doi.org/10.1016/j.mex.2025.103666</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.mex.2025.103666" target="_blank" >10.1016/j.mex.2025.103666</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Evaluation of targeted and high-resolution mass spectrometry methods for environmental monitoring of pharmaceuticals

Popis výsledku v původním jazyce

This study presents a comparison of three mass spectrometry-based analytical approaches-targeted tandem mass spectrometry (MS/MS), high-resolution full scan (HRFS), and data-independent acquisition (DIA)-for the quantification and screening of 74 pharmaceuticals across four environmental water matrices: tap water, river water, and influent and effluent wastewater. The methods were validated in terms of limits of quantification (LOQ), trueness, precision, and matrix effects. MS/MS exhibited the best overall performance, achieving the lowest LOQs (median 0.54 ng/L), highest trueness (median 101 %), and minimal matrix effects, confirming its suitability for routine regulatory monitoring. HRFS and DIA, while showing higher LOQs and variability, provided broader screening capabilities with acceptable trueness for 63 % and 81 % of compounds, respectively, and enabled retrospective data analysis. The methods were applied to real samples from the Zivn &amp; yacute; Stream in the Czech Republic to determine pharmaceutical contamination downstream of a wastewater treatment plant (WWTP).

Název v anglickém jazyce

Evaluation of targeted and high-resolution mass spectrometry methods for environmental monitoring of pharmaceuticals

Popis výsledku anglicky

This study presents a comparison of three mass spectrometry-based analytical approaches-targeted tandem mass spectrometry (MS/MS), high-resolution full scan (HRFS), and data-independent acquisition (DIA)-for the quantification and screening of 74 pharmaceuticals across four environmental water matrices: tap water, river water, and influent and effluent wastewater. The methods were validated in terms of limits of quantification (LOQ), trueness, precision, and matrix effects. MS/MS exhibited the best overall performance, achieving the lowest LOQs (median 0.54 ng/L), highest trueness (median 101 %), and minimal matrix effects, confirming its suitability for routine regulatory monitoring. HRFS and DIA, while showing higher LOQs and variability, provided broader screening capabilities with acceptable trueness for 63 % and 81 % of compounds, respectively, and enabled retrospective data analysis. The methods were applied to real samples from the Zivn &amp; yacute; Stream in the Czech Republic to determine pharmaceutical contamination downstream of a wastewater treatment plant (WWTP).

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10406 - Analytical chemistry

Projekt

<a href="/cs/project/GA22-03754S" target="_blank" >GA22-03754S: Od mozku ke spermiím: jak mohou psychoaktivní polutanty ovlivnit funkci spermií ryb.</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

MethodsX

ISSN

—

e-ISSN

2215-0161

Svazek periodika

15

Číslo periodika v rámci svazku

neuvedeno

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

10

Strana od-do

nestránkováno

Kód UT WoS článku

001593020000002

EID výsledku v databázi Scopus

2-s2.0-105018093958