Eyes as a Novel Target of Psychoactive Contaminants in Fish

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12520%2F25%3A43910065" target="_blank" >RIV/60076658:12520/25:43910065 - isvavai.cz</a>

Výsledek na webu

<a href="https://doi.org/10.1021/acs.estlett.5c00607" target="_blank" >https://doi.org/10.1021/acs.estlett.5c00607</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1021/acs.estlett.5c00607" target="_blank" >10.1021/acs.estlett.5c00607</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Eyes as a Novel Target of Psychoactive Contaminants in Fish

Popis výsledku v původním jazyce

Psychoactive drugs are prevalent aquatic contaminants that target neurotransmitter systems conserved across vertebrates. While their effects on fish brain chemistry and behavior are increasingly recognized, impacts on sensory systems such as vision remain largely unexamined. Here, we demonstrate that environmentally relevant mixtures of psychoactive drugs accumulate in the eyes of European perch (Perca fluviatilis) under both laboratory and field conditions, often at higher concentrations than in the brain. This ocular accumulation significantly alters neurotransmitter levels critical to visual processing. Our findings reveal a previously overlooked mechanism of sensory disruption with potential consequences for fish behavior, ecological interactions, and population fitness. Current environmental risk assessments, which rarely consider the visual system, may therefore underestimate the ecological impact of pharmaceutical pollution. These results underscore the need to expand ecotoxicological frameworks to include sensory endpoints and visual function as sensitive indicators of contaminant exposure in aquatic organisms.

Název v anglickém jazyce

Eyes as a Novel Target of Psychoactive Contaminants in Fish

Popis výsledku anglicky

Psychoactive drugs are prevalent aquatic contaminants that target neurotransmitter systems conserved across vertebrates. While their effects on fish brain chemistry and behavior are increasingly recognized, impacts on sensory systems such as vision remain largely unexamined. Here, we demonstrate that environmentally relevant mixtures of psychoactive drugs accumulate in the eyes of European perch (Perca fluviatilis) under both laboratory and field conditions, often at higher concentrations than in the brain. This ocular accumulation significantly alters neurotransmitter levels critical to visual processing. Our findings reveal a previously overlooked mechanism of sensory disruption with potential consequences for fish behavior, ecological interactions, and population fitness. Current environmental risk assessments, which rarely consider the visual system, may therefore underestimate the ecological impact of pharmaceutical pollution. These results underscore the need to expand ecotoxicological frameworks to include sensory endpoints and visual function as sensitive indicators of contaminant exposure in aquatic organisms.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10511 - Environmental sciences (social aspects to be 5.7)

Projekt

<a href="/cs/project/GA22-03754S" target="_blank" >GA22-03754S: Od mozku ke spermiím: jak mohou psychoaktivní polutanty ovlivnit funkci spermií ryb.</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Environmental Science &amp; Technology Letters

ISSN

2328-8930

e-ISSN

2328-8930

Svazek periodika

12

Číslo periodika v rámci svazku

10

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

7

Strana od-do

1301-1307

Kód UT WoS článku

001535134500001

EID výsledku v databázi Scopus

2-s2.0-105018581778