Bioaccumulation of psychoactive contaminants and their effects on brain–gonad–sperm neurotransmitter networks in fish

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985874%3A_____%2F25%3A00643137" target="_blank" >RIV/67985874:_____/25:00643137 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/60076658:12520/25:43910170

Výsledek na webu

<a href="https://pubs.acs.org/doi/10.1021/acs.est.5c07762" target="_blank" >https://pubs.acs.org/doi/10.1021/acs.est.5c07762</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1021/acs.est.5c07762" target="_blank" >10.1021/acs.est.5c07762</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Bioaccumulation of psychoactive contaminants and their effects on brain–gonad–sperm neurotransmitter networks in fish

Popis výsledku v původním jazyce

Psychoactive compounds (PSYCs) in aquatic environments raise concern due to the evolutionary conservation of neurotransmitter systems across vertebrates. While their potential to affect neural function is increasingly recognized, much less is known about their influence on fish reproduction, which relies on neurotransmitters both via the brain−gonadal axis and directly within sperm, independent of neural control. Here, we investigated the effects of environmentally relevant concentrations of a mixture of seven PSYCs (citalopram, donepezil, gabapentin, methamphetamine, sertraline, tramadol, and venlafaxine) on European perch (Perca fluviatilis) during a 23 day exposure. Neurotransmitter levels were quantified in brain, gonads, and sperm using LC−HRMS/MS, accompanied by bioaccumulation assessment, histopathology, and sperm quality analysis. All tested compounds bioaccumulated in brain and gonads and, notably, in sperm. Exposure to PSYCs modified neurotransmitter levels across tissues, disrupting correlation patterns between neurochemicals in brain, gonads, and sperm. No significant changes were observed in gonadal histopathology or sperm-quality parameters. However, the observed molecular alterations suggest potential consequences under longer or chronic exposures. These findings identify sperm as a previously overlooked target for psychoactive pollutants and reveal neurochemical disruption along the brain−gonad−sperm axis as a previously unrecognized mechanism through which PSYCs may affect fish physiology.n

Název v anglickém jazyce

Bioaccumulation of psychoactive contaminants and their effects on brain–gonad–sperm neurotransmitter networks in fish

Popis výsledku anglicky

Psychoactive compounds (PSYCs) in aquatic environments raise concern due to the evolutionary conservation of neurotransmitter systems across vertebrates. While their potential to affect neural function is increasingly recognized, much less is known about their influence on fish reproduction, which relies on neurotransmitters both via the brain−gonadal axis and directly within sperm, independent of neural control. Here, we investigated the effects of environmentally relevant concentrations of a mixture of seven PSYCs (citalopram, donepezil, gabapentin, methamphetamine, sertraline, tramadol, and venlafaxine) on European perch (Perca fluviatilis) during a 23 day exposure. Neurotransmitter levels were quantified in brain, gonads, and sperm using LC−HRMS/MS, accompanied by bioaccumulation assessment, histopathology, and sperm quality analysis. All tested compounds bioaccumulated in brain and gonads and, notably, in sperm. Exposure to PSYCs modified neurotransmitter levels across tissues, disrupting correlation patterns between neurochemicals in brain, gonads, and sperm. No significant changes were observed in gonadal histopathology or sperm-quality parameters. However, the observed molecular alterations suggest potential consequences under longer or chronic exposures. These findings identify sperm as a previously overlooked target for psychoactive pollutants and reveal neurochemical disruption along the brain−gonad−sperm axis as a previously unrecognized mechanism through which PSYCs may affect fish physiology.n

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10511 - Environmental sciences (social aspects to be 5.7)

Projekt

<a href="/cs/project/GA22-03754S" target="_blank" >GA22-03754S: Od mozku ke spermiím: jak mohou psychoaktivní polutanty ovlivnit funkci spermií ryb.</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Environmental Science & Technology

ISSN

0013-936X

e-ISSN

1520-5851

Svazek periodika

59

Číslo periodika v rámci svazku

50

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

16

Strana od-do

27556-27571

Kód UT WoS článku

001634105100001

EID výsledku v databázi Scopus

2-s2.0-105025206802