AN ASYMMETRIC APPROACH TO THE RADIOSYNTHESIS OF BOTH ENANTIOMERS OF alpha-[C-11]METHYLDOPA AND alpha-[C-11]METHYLTYROSINE FOR POSITRON EMISSION TOMOGRAPHY

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12640%2F06%3A00010093" target="_blank" >RIV/60076658:12640/06:00010093 - isvavai.cz</a>

Výsledek na webu

—

DOI - Digital Object Identifier

—

Jazyk výsledku

angličtina

Název v původním jazyce

AN ASYMMETRIC APPROACH TO THE RADIOSYNTHESIS OF BOTH ENANTIOMERS OF alpha-[C-11]METHYLDOPA AND alpha-[C-11]METHYLTYROSINE FOR POSITRON EMISSION TOMOGRAPHY

Popis výsledku v původním jazyce

In PET, alpha-methyl amino acids can play a dual role: a) precursors of neurotransmitters analogues for the study of neurodegenerative diseases; b) non-metabolised analogues of proteinogenic amino acids for the study of amino acids uptake into normal andcancer cells. The difference in the uptake rates during a PET scan could visualise cancer cells in a human body. Clinical applications of such amino acids are strongly limited due to their poor availability. For the synthesis of alpha-[C-11]methyltryptophan, an industrial procedure was adopted. All attempts to prepare enantiomerically pure alpha[C-11]methylated tyrosine failed. We carried out [C-11] methylation of metalocomplex synthons derived from protected DOPA or tyrosine. Individual diastereomerswere successfully separated by preparative HPLC, diluted with excess of water and extracted on C-18 cartridges. Optimisation of the procedure followed by hydrolysis of the complexes and purification of the enantiomers of alpha[C-11] methy

Název v anglickém jazyce

AN ASYMMETRIC APPROACH TO THE RADIOSYNTHESIS OF BOTH ENANTIOMERS OF alpha-[C-11]METHYLDOPA AND alpha-[C-11]METHYLTYROSINE FOR POSITRON EMISSION TOMOGRAPHY

Popis výsledku anglicky

In PET, alpha-methyl amino acids can play a dual role: a) precursors of neurotransmitters analogues for the study of neurodegenerative diseases; b) non-metabolised analogues of proteinogenic amino acids for the study of amino acids uptake into normal andcancer cells. The difference in the uptake rates during a PET scan could visualise cancer cells in a human body. Clinical applications of such amino acids are strongly limited due to their poor availability. For the synthesis of alpha-[C-11]methyltryptophan, an industrial procedure was adopted. All attempts to prepare enantiomerically pure alpha[C-11]methylated tyrosine failed. We carried out [C-11] methylation of metalocomplex synthons derived from protected DOPA or tyrosine. Individual diastereomerswere successfully separated by preparative HPLC, diluted with excess of water and extracted on C-18 cartridges. Optimisation of the procedure followed by hydrolysis of the complexes and purification of the enantiomers of alpha[C-11] methy

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

BO - Biofyzika

OECD FORD obor

—

Projekt

—

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2006

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Czechoslovak Journal of Physics

ISSN

0011-4626

e-ISSN

—

Svazek periodika

56

Číslo periodika v rámci svazku

suppl.4

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

5

Strana od-do

—

Kód UT WoS článku

000206057500085

EID výsledku v databázi Scopus

—