Development of metallocomplex amino acids synthons for the asymmetric preparation of alfa-amino acids by stereoselective introduction of a side chain. Evaluation of the model asymmetric preparation of alanine and beta-C-13 monolabelled alfa-aminoisobutyric acid

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216275%3A25310%2F10%3A39881300" target="_blank" >RIV/00216275:25310/10:39881300 - isvavai.cz</a>

Výsledek na webu

—

DOI - Digital Object Identifier

—

Jazyk výsledku

angličtina

Název v původním jazyce

Development of metallocomplex amino acids synthons for the asymmetric preparation of alfa-amino acids by stereoselective introduction of a side chain. Evaluation of the model asymmetric preparation of alanine and beta-C-13 monolabelled alfa-aminoisobutyric acid

Popis výsledku v původním jazyce

The evaluation of 11 new metallocomplex alanine synthons bearing C-2-symmetric benzyl groups with electron-donating and withdrawing substituents is described. alpha-Methylated glycine synthons (alanine complexes) were evaluated alongside alanine synthonsin order to obtain a deeper understanding of the relationship between their structures and stereochemistry of monoalkylated products and to choose several candidates for their further tests for stereospecific preparation of 6-[F-18]FDOPA. Glycine-derived analogues of the complexes 3-5 are the best candidates for the development of a 6-[F-18]FDOPA preparation procedure. In the model epimerisation reaction they demonstrated the best performance, much better compared to the previously described compound 2. Complexes 3, 5 and 8 are the best in asymmetric preparation of beta-C-13 monolabelled alpha-aminoisobutyric acid. They have to be tested in the preparation of alpha-methyl amino acids like 6-[F-18]-alpha-methylDOPA and 2-[F-18]-alpha-me

Název v anglickém jazyce

Development of metallocomplex amino acids synthons for the asymmetric preparation of alfa-amino acids by stereoselective introduction of a side chain. Evaluation of the model asymmetric preparation of alanine and beta-C-13 monolabelled alfa-aminoisobutyric acid

Popis výsledku anglicky

The evaluation of 11 new metallocomplex alanine synthons bearing C-2-symmetric benzyl groups with electron-donating and withdrawing substituents is described. alpha-Methylated glycine synthons (alanine complexes) were evaluated alongside alanine synthonsin order to obtain a deeper understanding of the relationship between their structures and stereochemistry of monoalkylated products and to choose several candidates for their further tests for stereospecific preparation of 6-[F-18]FDOPA. Glycine-derived analogues of the complexes 3-5 are the best candidates for the development of a 6-[F-18]FDOPA preparation procedure. In the model epimerisation reaction they demonstrated the best performance, much better compared to the previously described compound 2. Complexes 3, 5 and 8 are the best in asymmetric preparation of beta-C-13 monolabelled alpha-aminoisobutyric acid. They have to be tested in the preparation of alpha-methyl amino acids like 6-[F-18]-alpha-methylDOPA and 2-[F-18]-alpha-me

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CC - Organická chemie

OECD FORD obor

—

Projekt

—

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2010

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Radioanalytical and Nuclear Chemistry

ISSN

0236-5731

e-ISSN

—

Svazek periodika

285

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

6

Strana od-do

—

Kód UT WoS článku

000281089300030

EID výsledku v databázi Scopus

—