Development of metallcomplex amino acids synthons for the asymmetric preparation of alpha-amino acids by stereoselective introduction of a side chain

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F70883521%3A28110%2F10%3A63510063" target="_blank" >RIV/70883521:28110/10:63510063 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Development of metallcomplex amino acids synthons for the asymmetric preparation of alpha-amino acids by stereoselective introduction of a side chain

Popis výsledku v původním jazyce

In this communication the evaluation of eleven new metalocomplex alanine synthons bearing C2-symmetric benzyl groups with electron-donating and electron-withdrawing substituents is described. Alpha-Methylated glycine synthons (alanine complexes) were evaluated alongside alanine synthons in order to obtain a deeper understanding of the relationship between their structures and stereochemistry of monoalkylated products and to choose several candidates for their further tests for stereospecific preparationof 6-[18F]FDOPA. Glycine-derived analogues of the complexes 3-5 are the best candidates for the development of a 6-[18F]FDOPA preparation procedure. In the model epimerization reaction they demonstrated the best performance, much better compared to thepreviously described compound 2. Complexes 3, 5, and 8 are the best in asymmetric preparation of beta-13C monolabelled alpha-aminoisobutyric acid. The have to be tested in the preparation of alpha-methyl amino acids like 6-[18F]-alpha-met

Název v anglickém jazyce

Development of metallcomplex amino acids synthons for the asymmetric preparation of alpha-amino acids by stereoselective introduction of a side chain

Popis výsledku anglicky

In this communication the evaluation of eleven new metalocomplex alanine synthons bearing C2-symmetric benzyl groups with electron-donating and electron-withdrawing substituents is described. Alpha-Methylated glycine synthons (alanine complexes) were evaluated alongside alanine synthons in order to obtain a deeper understanding of the relationship between their structures and stereochemistry of monoalkylated products and to choose several candidates for their further tests for stereospecific preparationof 6-[18F]FDOPA. Glycine-derived analogues of the complexes 3-5 are the best candidates for the development of a 6-[18F]FDOPA preparation procedure. In the model epimerization reaction they demonstrated the best performance, much better compared to thepreviously described compound 2. Complexes 3, 5, and 8 are the best in asymmetric preparation of beta-13C monolabelled alpha-aminoisobutyric acid. The have to be tested in the preparation of alpha-methyl amino acids like 6-[18F]-alpha-met

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CC - Organická chemie

OECD FORD obor

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Projekt

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Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2010

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Radioanalytical Nuclear Chemistry

ISSN

0236-5731

e-ISSN

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Svazek periodika

285

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

6

Strana od-do

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Kód UT WoS článku

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EID výsledku v databázi Scopus

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