Identification and characterisation of lectins in several tick species

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F09%3A00336492" target="_blank" >RIV/60077344:_____/09:00336492 - isvavai.cz</a>

Výsledek na webu

—

DOI - Digital Object Identifier

—

Jazyk výsledku

angličtina

Název v původním jazyce

Identification and characterisation of lectins in several tick species

Popis výsledku v původním jazyce

FReD (fibrinogen-related domain) proteins are lectins with possible functions in immunity of invertebrates. Several FReD proteins were detected using antibodies directed against Dorin M, Ixodes ricinus hemolymph lectin, and hemagglutination acitivity ofO. moubata and I. ricinus ticks. All identified FReD proteins are modified by truncated high-mannose glycans. Hemagglutination activity of hemolymph of the studied ticks was inhibited predominantly by N-acetylhexosamines and sialoglycoproteins. All tickspecies contained a hemelipoglycoprotein-like protein. Nucleotide sequence of novel protein containing fibrinogen- related domain was identified in ticks of species D. marginatus, Haemaphysalis punctata, and Hyalomma impeltatus. FReD proteins of D. marginatus localised in hemocytes, salivary glands, and gut cells.

Název v anglickém jazyce

Identification and characterisation of lectins in several tick species

Popis výsledku anglicky

FReD (fibrinogen-related domain) proteins are lectins with possible functions in immunity of invertebrates. Several FReD proteins were detected using antibodies directed against Dorin M, Ixodes ricinus hemolymph lectin, and hemagglutination acitivity ofO. moubata and I. ricinus ticks. All identified FReD proteins are modified by truncated high-mannose glycans. Hemagglutination activity of hemolymph of the studied ticks was inhibited predominantly by N-acetylhexosamines and sialoglycoproteins. All tickspecies contained a hemelipoglycoprotein-like protein. Nucleotide sequence of novel protein containing fibrinogen- related domain was identified in ticks of species D. marginatus, Haemaphysalis punctata, and Hyalomma impeltatus. FReD proteins of D. marginatus localised in hemocytes, salivary glands, and gut cells.

Druh

O - Ostatní výsledky

CEP obor

CE - Biochemie

OECD FORD obor

—

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2009

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů