Post-transplant processing of superparamagnetic iron nanoparticles used for islet labeling and MR detection

Kód výsledku v IS VaVaI

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Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Post-transplant processing of superparamagnetic iron nanoparticles used for islet labeling and MR detection

Popis výsledku v původním jazyce

In vitro, ferucarbotran gradually incorporated into all types of islet cells and macrophages. First day after Tx, some particles were still in islet cell cytoplasm; however, many free iron particles were among the components released from the procedure-related destructed tissue. Components of dead cells including iron particles were engulfed by phagocytic cells. One week after Tx, ferucarbotran was rarely found in the endocrine cells, although the mechanism of iron release from beta-cells was not evident. Iron particles were stored in macrophages and in large fibroblast-resembling cells, which, however, were not positive for a fibroblast marker S100A4. One month after Tx, large amount of iron was concentrated in the islet surrounding macrophages and inthe cells enclosed by collagen producing fibroblasts. No iron particles were found in beta cells. 3 months after Tx the iron particles were still detected.

Název v anglickém jazyce

Post-transplant processing of superparamagnetic iron nanoparticles used for islet labeling and MR detection

Popis výsledku anglicky

In vitro, ferucarbotran gradually incorporated into all types of islet cells and macrophages. First day after Tx, some particles were still in islet cell cytoplasm; however, many free iron particles were among the components released from the procedure-related destructed tissue. Components of dead cells including iron particles were engulfed by phagocytic cells. One week after Tx, ferucarbotran was rarely found in the endocrine cells, although the mechanism of iron release from beta-cells was not evident. Iron particles were stored in macrophages and in large fibroblast-resembling cells, which, however, were not positive for a fibroblast marker S100A4. One month after Tx, large amount of iron was concentrated in the islet surrounding macrophages and inthe cells enclosed by collagen producing fibroblasts. No iron particles were found in beta cells. 3 months after Tx the iron particles were still detected.

Druh

O - Ostatní výsledky

CEP obor

FB - Endokrinologie, diabetologie, metabolismus, výživa

OECD FORD obor

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Projekt

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Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2009

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů