Processing of superparamagnetic iron contrast agent ferucarbotran in transplanted pancreatic islets
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F12%3A00386218" target="_blank" >RIV/60077344:_____/12:00386218 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/00023001:_____/12:00055971
Výsledek na webu
<a href="http://onlinelibrary.wiley.com/doi/10.1002/cmmi.1477/full" target="_blank" >http://onlinelibrary.wiley.com/doi/10.1002/cmmi.1477/full</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/cmmi.1477" target="_blank" >10.1002/cmmi.1477</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Processing of superparamagnetic iron contrast agent ferucarbotran in transplanted pancreatic islets
Popis výsledku v původním jazyce
Labeling of pancreatic islets with superparamagnetic iron oxide (SPIO) nanoparticles enables their post-transplant monitoring by magnetic resonance imaging (MRI). Although the nanoparticles are incorporated into islet cells in culture, little is known about their fate in vivo. We studied the morphology of labeled islets after transplantation, aiming to identify the MRI contrast particles and their relationship to transplantation outcomes. Rat islets labeled with the ferucarbotran were transplanted intothe liver or under the kidney capsule of syngeneic and allogeneic rats. After in vivo MRI, morphology was studied by light, fluorescence and transmission electron microscopy. Morphology of syngeneic islets transplanted beneath the kidney capsule vs intothe liver was similar. Iron particles were almost completely eliminated from the endocrine cells and remained located in host-derived macrophages surrounding the vital islets for the entire study period. In the allogeneic model, islets lo
Název v anglickém jazyce
Processing of superparamagnetic iron contrast agent ferucarbotran in transplanted pancreatic islets
Popis výsledku anglicky
Labeling of pancreatic islets with superparamagnetic iron oxide (SPIO) nanoparticles enables their post-transplant monitoring by magnetic resonance imaging (MRI). Although the nanoparticles are incorporated into islet cells in culture, little is known about their fate in vivo. We studied the morphology of labeled islets after transplantation, aiming to identify the MRI contrast particles and their relationship to transplantation outcomes. Rat islets labeled with the ferucarbotran were transplanted intothe liver or under the kidney capsule of syngeneic and allogeneic rats. After in vivo MRI, morphology was studied by light, fluorescence and transmission electron microscopy. Morphology of syngeneic islets transplanted beneath the kidney capsule vs intothe liver was similar. Iron particles were almost completely eliminated from the endocrine cells and remained located in host-derived macrophages surrounding the vital islets for the entire study period. In the allogeneic model, islets lo
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
CE - Biochemie
OECD FORD obor
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Návaznosti výsledku
Projekt
—
Návaznosti
Z - Vyzkumny zamer (s odkazem do CEZ)
Ostatní
Rok uplatnění
2012
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Contrast Media & Molecular Imaging
ISSN
1555-4309
e-ISSN
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Svazek periodika
7
Číslo periodika v rámci svazku
6
Stát vydavatele periodika
GB - Spojené království Velké Británie a Severního Irska
Počet stran výsledku
9
Strana od-do
485-493
Kód UT WoS článku
000308940900002
EID výsledku v databázi Scopus
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