Antitumor activity od apoptotic nuclease TBN1 from L. esculentum

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F10%3A00346342" target="_blank" >RIV/60077344:_____/10:00346342 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/67985904:_____/10:00346342

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Antitumor activity od apoptotic nuclease TBN1 from L. esculentum

Popis výsledku v původním jazyce

Nuclease from tomato (TBN1) wad produced by in planta biotechnology, purified and tested for its antitumor properties. The nuclease was cytostatic after its intratumoral administration to nude mice bearing human melanoma or prostate carcinoma, and also after tumor targeting by its intravenous administration as conjugate with PEG. Inhibitory effects of TBN1 on tumor growth were comparable to effects of bovine seminal RNase (BS-RNase), but the inhibition was reached at about ten times lower protein concentration. Intravenous administration of TBN1-PEG caused significant inhibition of tumor proliferation without obvious degenerative changes, while direct administration of TBN1 into melanoma tumors led to rapid tumor tissue degeneration. Simultaneously, TBN1 exhibited a lower degree of embryotoxicity compared to BS-RNase and other nucleases.

Název v anglickém jazyce

Antitumor activity od apoptotic nuclease TBN1 from L. esculentum

Popis výsledku anglicky

Nuclease from tomato (TBN1) wad produced by in planta biotechnology, purified and tested for its antitumor properties. The nuclease was cytostatic after its intratumoral administration to nude mice bearing human melanoma or prostate carcinoma, and also after tumor targeting by its intravenous administration as conjugate with PEG. Inhibitory effects of TBN1 on tumor growth were comparable to effects of bovine seminal RNase (BS-RNase), but the inhibition was reached at about ten times lower protein concentration. Intravenous administration of TBN1-PEG caused significant inhibition of tumor proliferation without obvious degenerative changes, while direct administration of TBN1 into melanoma tumors led to rapid tumor tissue degeneration. Simultaneously, TBN1 exhibited a lower degree of embryotoxicity compared to BS-RNase and other nucleases.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FD - Onkologie a hematologie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2010

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Neoplasma

ISSN

0028-2685

e-ISSN

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Svazek periodika

57

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

SK - Slovenská republika

Počet stran výsledku

10

Strana od-do

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Kód UT WoS článku

000278262000008

EID výsledku v databázi Scopus

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