The nuclear receptor gene nhr-25 plays multiple roles in the Caenorhabditis elegans heterochronic gene network to control the larva-to-adult transition

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F10%3A00347271" target="_blank" >RIV/60077344:_____/10:00347271 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

The nuclear receptor gene nhr-25 plays multiple roles in the Caenorhabditis elegans heterochronic gene network to control the larva-to-adult transition

Popis výsledku v původním jazyce

Precise timing is essential for animal development. Its alteration, known as heterochrony, causes morphogenetic defects. Yet, little is known about the relationship between timing regulation and execution in terms of molecular action in the cell. Nuclearreceptors play multiple roles in animal development, and NHR-25, an ancient member of the family, is involved in morphogenesis of various tissues of the worm C. elegans. We demonstrated that NHR-25 genetically interacts with the pathway of heterochronicgenes including downstream targets of the let-7 microRNAs. NHR-25 together with the heterochronic genes modulates the timing of tissue-specific gene expression, cell fusion, cell division and cuticle formation. These data present the first example of anuclear receptor interaction with the heterochrony pathway.

Název v anglickém jazyce

The nuclear receptor gene nhr-25 plays multiple roles in the Caenorhabditis elegans heterochronic gene network to control the larva-to-adult transition

Popis výsledku anglicky

Precise timing is essential for animal development. Its alteration, known as heterochrony, causes morphogenetic defects. Yet, little is known about the relationship between timing regulation and execution in terms of molecular action in the cell. Nuclearreceptors play multiple roles in animal development, and NHR-25, an ancient member of the family, is involved in morphogenesis of various tissues of the worm C. elegans. We demonstrated that NHR-25 genetically interacts with the pathway of heterochronicgenes including downstream targets of the let-7 microRNAs. NHR-25 together with the heterochronic genes modulates the timing of tissue-specific gene expression, cell fusion, cell division and cuticle formation. These data present the first example of anuclear receptor interaction with the heterochrony pathway.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EB - Genetika a molekulární biologie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2010

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Developmental Biology

ISSN

0012-1606

e-ISSN

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Svazek periodika

344

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

10

Strana od-do

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Kód UT WoS článku

000280787100049

EID výsledku v databázi Scopus

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