Telomore maintenance on organisms without telomerase

Kód výsledku v IS VaVaI

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Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Telomore maintenance on organisms without telomerase

Popis výsledku v původním jazyce

Most eukaryotes elongate chromosome ends with telomerase that repeatedly adds copies of the short telomeric DNA sequence to the chromosome end. While there is strict conservation of telomeric sequence repeat in most species, the repeat unit has changed over evolutionary time. Lack of the predominant telomeric sequence in a species does not, however, signify that telomerase-generated terminal sequences are missing. Conversely, the presence of a canonical telomeric sequence does not necessarily indicate telomerase as a telomere maintenance mechanism. Although telomerase may have been the mechanism of telomere maintenance of the last common eukaryotic ancestor, it is not the only mechanism used to maintain chromosome length. Telomerase has been lost a fewtimes in the evolution of plants and animals. During insect evolution, for example, telomerase has been lost at least six times. Here, we discuss telomere maintenance mechanisms that replaced telomerase in telomere length maintenance.

Název v anglickém jazyce

Telomore maintenance on organisms without telomerase

Popis výsledku anglicky

Most eukaryotes elongate chromosome ends with telomerase that repeatedly adds copies of the short telomeric DNA sequence to the chromosome end. While there is strict conservation of telomeric sequence repeat in most species, the repeat unit has changed over evolutionary time. Lack of the predominant telomeric sequence in a species does not, however, signify that telomerase-generated terminal sequences are missing. Conversely, the presence of a canonical telomeric sequence does not necessarily indicate telomerase as a telomere maintenance mechanism. Although telomerase may have been the mechanism of telomere maintenance of the last common eukaryotic ancestor, it is not the only mechanism used to maintain chromosome length. Telomerase has been lost a fewtimes in the evolution of plants and animals. During insect evolution, for example, telomerase has been lost at least six times. Here, we discuss telomere maintenance mechanisms that replaced telomerase in telomere length maintenance.

Druh

C - Kapitola v odborné knize

CEP obor

EB - Genetika a molekulární biologie

OECD FORD obor

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Projekt

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Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2011

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

DNA Replication-Current Advances

ISBN

978-953-307-593-8

Počet stran výsledku

24

Strana od-do

323-346

Počet stran knihy

694

Název nakladatele

InTech

Místo vydání

Rijeka

Kód UT WoS kapitoly

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