Telomeres: Their structure and maintenance

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F13%3A00390569" target="_blank" >RIV/60077344:_____/13:00390569 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.5772/51356" target="_blank" >http://dx.doi.org/10.5772/51356</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.5772/51356" target="_blank" >10.5772/51356</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Telomeres: Their structure and maintenance

Popis výsledku v původním jazyce

Telomeres are essential nucleoprotein structures at the ends of eukaryotic chromosomes. They play several essential roles preserving genome stability and function. In the absence of special telomere maintenance mechanisms telomeres shorten with every round of DNA replication. The telomere shortening leads to replicative senescence and apoptosis. Several telomere maintenance mechanisms have been identified; these are reflected in several known types of telomeres. In most eukaryotes telomeres comprise a tandem array of a short, 5-8 bp, well conserved repeat unit, and telomere length is maintained by telomerase, a specialized reverse transcriptase that carries its own RNA template and adds telomeric sequences onto chromosome ends. Nevertheless, in some organisms the array of short telomeric sequence motifs has been replaced with less conventional sequences, such as satellite sequences or transposable elements.

Název v anglickém jazyce

Telomeres: Their structure and maintenance

Popis výsledku anglicky

Telomeres are essential nucleoprotein structures at the ends of eukaryotic chromosomes. They play several essential roles preserving genome stability and function. In the absence of special telomere maintenance mechanisms telomeres shorten with every round of DNA replication. The telomere shortening leads to replicative senescence and apoptosis. Several telomere maintenance mechanisms have been identified; these are reflected in several known types of telomeres. In most eukaryotes telomeres comprise a tandem array of a short, 5-8 bp, well conserved repeat unit, and telomere length is maintained by telomerase, a specialized reverse transcriptase that carries its own RNA template and adds telomeric sequences onto chromosome ends. Nevertheless, in some organisms the array of short telomeric sequence motifs has been replaced with less conventional sequences, such as satellite sequences or transposable elements.

Druh

C - Kapitola v odborné knize

CEP obor

EB - Genetika a molekulární biologie

OECD FORD obor

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Projekt

<a href="/cs/project/GAP501%2F10%2F1215" target="_blank" >GAP501/10/1215: Stresové hormony a jejich potenciální využití v kontrole hmyzích populací</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

The Mechanisms of DNA Replication

ISBN

978-953-51-0991-4

Počet stran výsledku

21

Strana od-do

423-443

Počet stran knihy

611

Název nakladatele

InTech, Open Access Publisher

Místo vydání

Rijeka

Kód UT WoS kapitoly

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