Gene fragmentation: a key to mitochondrial genome evolution in Euglenozoa?

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F11%3A00364837" target="_blank" >RIV/60077344:_____/11:00364837 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/60076658:12310/11:43869820

Výsledek na webu

<a href="http://dx.doi.org/10.1007/s00294-011-0340-8" target="_blank" >http://dx.doi.org/10.1007/s00294-011-0340-8</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00294-011-0340-8" target="_blank" >10.1007/s00294-011-0340-8</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Gene fragmentation: a key to mitochondrial genome evolution in Euglenozoa?

Popis výsledku v původním jazyce

Gene fragmentation is a striking feature of both euglenid and diplonemid mtDNAs. To rationalize the emergence of these highly divergent mtDNA types and the existence of insertion/deletion RNA editing (in kinetoplastids) and trans-splicing (in diplonemids), we propose that in the mitochondrion of the common evolutionary ancestor of Euglenozoa, small expressed gene fragments promoted a rampant neutral evolutionary pathway. Interactions between small antisense transcripts of these gene fragments and full-length transcripts, assisted by RNA-processing enzymes, permitted the emergence of RNA editing and/or trans-splicing activities, allowing the system to tolerate indel mutations and further gene fragmentation, respectively, and leading to accumulation of additional mutations. In this way, dramatically different mitochondrial genome structures and RNA-processing machineries were able to evolve.

Název v anglickém jazyce

Gene fragmentation: a key to mitochondrial genome evolution in Euglenozoa?

Popis výsledku anglicky

Gene fragmentation is a striking feature of both euglenid and diplonemid mtDNAs. To rationalize the emergence of these highly divergent mtDNA types and the existence of insertion/deletion RNA editing (in kinetoplastids) and trans-splicing (in diplonemids), we propose that in the mitochondrion of the common evolutionary ancestor of Euglenozoa, small expressed gene fragments promoted a rampant neutral evolutionary pathway. Interactions between small antisense transcripts of these gene fragments and full-length transcripts, assisted by RNA-processing enzymes, permitted the emergence of RNA editing and/or trans-splicing activities, allowing the system to tolerate indel mutations and further gene fragmentation, respectively, and leading to accumulation of additional mutations. In this way, dramatically different mitochondrial genome structures and RNA-processing machineries were able to evolve.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EB - Genetika a molekulární biologie

OECD FORD obor

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Projekt

—

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2011

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Current Genetics

ISSN

0172-8083

e-ISSN

—

Svazek periodika

57

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

8

Strana od-do

225-232

Kód UT WoS článku

000292977000001

EID výsledku v databázi Scopus

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