Relation of genetic phylogeny and geographical distance of tick-borne encephalitis virus in central Europe

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F11%3A00364901" target="_blank" >RIV/60077344:_____/11:00364901 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1099/vir.0.032417-0" target="_blank" >http://dx.doi.org/10.1099/vir.0.032417-0</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1099/vir.0.032417-0" target="_blank" >10.1099/vir.0.032417-0</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Relation of genetic phylogeny and geographical distance of tick-borne encephalitis virus in central Europe

Popis výsledku v původním jazyce

Tick-borne encephalitis virus (TBEV) is the most important arboviral agent causing disease of the central nervous system in central Europe. In this study, 61 TBEV E gene sequences derived from 48 isolates from the Czech Republic (CR), and 4 isolates and9 TBEV strains detected in ticks from Germany (1954 to 2009), were sequenced and subjected to phylogenetic and Bayesian phylodynamic. The general Eurasian continental east-to-west pattern of the spread of TBEV was confirmed at the regional level but is interlaced with spreading that arises because of local geography and anthropogenic influence. This spread is reflected by the disease pattern in the CR that has been observed since 1991. The overall evolutionary rate was estimated to be approximately 8x10(-4) substitutions per nucleotide per year. The analysis of the TBEV E genes of 11 strains isolated at one natural focus in Zd'ar Kaplice proved for the first time that TBEV is indeed subject to local evolution.

Název v anglickém jazyce

Relation of genetic phylogeny and geographical distance of tick-borne encephalitis virus in central Europe

Popis výsledku anglicky

Tick-borne encephalitis virus (TBEV) is the most important arboviral agent causing disease of the central nervous system in central Europe. In this study, 61 TBEV E gene sequences derived from 48 isolates from the Czech Republic (CR), and 4 isolates and9 TBEV strains detected in ticks from Germany (1954 to 2009), were sequenced and subjected to phylogenetic and Bayesian phylodynamic. The general Eurasian continental east-to-west pattern of the spread of TBEV was confirmed at the regional level but is interlaced with spreading that arises because of local geography and anthropogenic influence. This spread is reflected by the disease pattern in the CR that has been observed since 1991. The overall evolutionary rate was estimated to be approximately 8x10(-4) substitutions per nucleotide per year. The analysis of the TBEV E genes of 11 strains isolated at one natural focus in Zd'ar Kaplice proved for the first time that TBEV is indeed subject to local evolution.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EE - Mikrobiologie, virologie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2011

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of General Virology

ISSN

0022-1317

e-ISSN

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Svazek periodika

92

Číslo periodika v rámci svazku

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Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

11

Strana od-do

1906-1916

Kód UT WoS článku

000293488800020

EID výsledku v databázi Scopus

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