Parallels in understanding the endocrine control of lifespan with the firebug Pyrrhocoris apterus and the fruit fly Drosophila melanogaster

Kód výsledku v IS VaVaI

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Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Parallels in understanding the endocrine control of lifespan with the firebug Pyrrhocoris apterus and the fruit fly Drosophila melanogaster

Popis výsledku v původním jazyce

In many organisms reproduction is negatively correlated with lifespan. Juvenile hormone (JH) is currently considered to play a key role in the modulation of this trade-off in insects but the way it does so remains unknown. Complementary approaches in twomodels, the firebug P. apterus and the genetic workhorse Drosophila melanogaster, help to uncover these mechanisms. Hypothetically, JH might accelerate aging via its well-documented stimulating effect on reproduction. Combination of surgical interventions in Pyrrhocoris apterus demonstrated that egg production itself is not the mechanism by which JH accelerates aging. Yet, the genetic approach in D. melanogaster revealed that reproduction still seems to be central to the hormonal control of aging via hypothesized endocrine signals produced by the somatic gonad that are regulated by germ line stem cells.

Název v anglickém jazyce

Parallels in understanding the endocrine control of lifespan with the firebug Pyrrhocoris apterus and the fruit fly Drosophila melanogaster

Popis výsledku anglicky

In many organisms reproduction is negatively correlated with lifespan. Juvenile hormone (JH) is currently considered to play a key role in the modulation of this trade-off in insects but the way it does so remains unknown. Complementary approaches in twomodels, the firebug P. apterus and the genetic workhorse Drosophila melanogaster, help to uncover these mechanisms. Hypothetically, JH might accelerate aging via its well-documented stimulating effect on reproduction. Combination of surgical interventions in Pyrrhocoris apterus demonstrated that egg production itself is not the mechanism by which JH accelerates aging. Yet, the genetic approach in D. melanogaster revealed that reproduction still seems to be central to the hormonal control of aging via hypothesized endocrine signals produced by the somatic gonad that are regulated by germ line stem cells.

Druh

C - Kapitola v odborné knize

CEP obor

ED - Fyziologie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2011

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

Mechanisms of Life History Evolution. The Genetics and Physiology of Life History Traits and Trade-offs

ISBN

978-0-19-956877-2

Počet stran výsledku

9

Strana od-do

171-179

Počet stran knihy

478

Název nakladatele

Oxford University Press

Místo vydání

Oxford

Kód UT WoS kapitoly

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