Viroids: The Smallest Known Infectious Agents Cause Accumulation of Viroid-Specific Small RNAs

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F12%3A00378833" target="_blank" >RIV/60077344:_____/12:00378833 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1007/978-3-642-27426-8_26" target="_blank" >http://dx.doi.org/10.1007/978-3-642-27426-8_26</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/978-3-642-27426-8_26" target="_blank" >10.1007/978-3-642-27426-8_26</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Viroids: The Smallest Known Infectious Agents Cause Accumulation of Viroid-Specific Small RNAs

Popis výsledku v původním jazyce

Viroids are plant-infectious, non-coding, unencapsidated, circular RNAs ranging in size from 250 to 400 nucleotides that are transcribed in a rolling-circle mechanism either in nuclei (Pospiviroidae) or in chloroplasts (Avsunviroidae) of hosts. The pathogenic effect caused by viroids is still an enigma: Potato spindle tuber viroid (PSTVd), the type strain of Pospiviroidae, causes typical symptoms in tomato plants but the severity of symptoms depends on the tomato cultivar; different strains of PSTVd, which vary in sequence by a few mutations from each other, induce symptoms from very mild up to necrosis upon infection of a cultivar. According to recent findings viroids cause the accumulation of viroid-specific small RNAs (vsRNA) similar in size to small interfering (siRNA) and miRNAs, but they do escape the cytoplasmic silencing mechanism. In this review we discuss these findings and hypotheses on the biogenesis of viroid-specific small RNAs and connections to symptom induction.

Název v anglickém jazyce

Viroids: The Smallest Known Infectious Agents Cause Accumulation of Viroid-Specific Small RNAs

Popis výsledku anglicky

Viroids are plant-infectious, non-coding, unencapsidated, circular RNAs ranging in size from 250 to 400 nucleotides that are transcribed in a rolling-circle mechanism either in nuclei (Pospiviroidae) or in chloroplasts (Avsunviroidae) of hosts. The pathogenic effect caused by viroids is still an enigma: Potato spindle tuber viroid (PSTVd), the type strain of Pospiviroidae, causes typical symptoms in tomato plants but the severity of symptoms depends on the tomato cultivar; different strains of PSTVd, which vary in sequence by a few mutations from each other, induce symptoms from very mild up to necrosis upon infection of a cultivar. According to recent findings viroids cause the accumulation of viroid-specific small RNAs (vsRNA) similar in size to small interfering (siRNA) and miRNAs, but they do escape the cytoplasmic silencing mechanism. In this review we discuss these findings and hypotheses on the biogenesis of viroid-specific small RNAs and connections to symptom induction.

Druh

C - Kapitola v odborné knize

CEP obor

EB - Genetika a molekulární biologie

OECD FORD obor

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Projekt

<a href="/cs/project/GCP501%2F10%2FJ018" target="_blank" >GCP501/10/J018: Pospiviroidní patogeneze jako regulační porucha zprostředkovaná malými viroid-specifickými RNA.</a><br>

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

From Nucleic Acids Sequences to Molecular Medicine

ISBN

978-3-642-27425-1

Počet stran výsledku

16

Strana od-do

629-644

Počet stran knihy

654

Název nakladatele

Springer Berlin Heidelberg

Místo vydání

Berlin/Heidelberg

Kód UT WoS kapitoly

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