Effect of tick saliva on signalling pathways activated by TLR-2 ligand and Borrelia afzelii in dendritic cells

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F12%3A00387477" target="_blank" >RIV/60077344:_____/12:00387477 - isvavai.cz</a>

Výsledek na webu

<a href="http://onlinelibrary.wiley.com/doi/10.1111/j.1365-3024.2012.01375.x/abstract" target="_blank" >http://onlinelibrary.wiley.com/doi/10.1111/j.1365-3024.2012.01375.x/abstract</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/j.1365-3024.2011.01345.x" target="_blank" >10.1111/j.1365-3024.2011.01345.x</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Effect of tick saliva on signalling pathways activated by TLR-2 ligand and Borrelia afzelii in dendritic cells

Popis výsledku v původním jazyce

Dendritic cells are a sentinel in defending against pathogens and tick saliva facilitates transmission of tick-borne pathogens by modulating the host immune response. The maturation of dendritic cells is inhibited by tick saliva. To elucidate the mechanism of this inhibition, we tested the impact of Ixodes ricinus tick saliva on signalling pathways activated by Toll-like receptor (TLR-2) ligand and Borrelia afzelii in spleen dendritic cells. The activation of nuclear factor-jB (NF-jB) p65 and phosphatidylinositol-3 kinase (PI3K)/ Akt pathways was decreased by tick saliva upon both TLR- 2 and Borrelia stimulation. Among the mitogen-activated protein kinases (MAPK), the activation of extracellular matrix-regulated kinase (Erk1/ 2) was suppressed by ticksaliva, but not p38. In response to spirochaetes, the amount of TNF-a decreased in the presence of tick saliva which was mediated by selective suppression of Erk1/ 2, NF-jB and Akt as tick saliva mimicked the effect of their specific inhi

Název v anglickém jazyce

Effect of tick saliva on signalling pathways activated by TLR-2 ligand and Borrelia afzelii in dendritic cells

Popis výsledku anglicky

Dendritic cells are a sentinel in defending against pathogens and tick saliva facilitates transmission of tick-borne pathogens by modulating the host immune response. The maturation of dendritic cells is inhibited by tick saliva. To elucidate the mechanism of this inhibition, we tested the impact of Ixodes ricinus tick saliva on signalling pathways activated by Toll-like receptor (TLR-2) ligand and Borrelia afzelii in spleen dendritic cells. The activation of nuclear factor-jB (NF-jB) p65 and phosphatidylinositol-3 kinase (PI3K)/ Akt pathways was decreased by tick saliva upon both TLR- 2 and Borrelia stimulation. Among the mitogen-activated protein kinases (MAPK), the activation of extracellular matrix-regulated kinase (Erk1/ 2) was suppressed by ticksaliva, but not p38. In response to spirochaetes, the amount of TNF-a decreased in the presence of tick saliva which was mediated by selective suppression of Erk1/ 2, NF-jB and Akt as tick saliva mimicked the effect of their specific inhi

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EC - Imunologie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Parasite immunology

ISSN

0141-9838

e-ISSN

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Svazek periodika

35

Číslo periodika v rámci svazku

8-9

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

9

Strana od-do

421-429

Kód UT WoS článku

000307105500004

EID výsledku v databázi Scopus

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