Molecular characterization of the African orthobunyavirus Ilesha virus

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F13%3A00397210" target="_blank" >RIV/60077344:_____/13:00397210 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00027162:_____/13:#0001050

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.meegid.2013.08.015" target="_blank" >http://dx.doi.org/10.1016/j.meegid.2013.08.015</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.meegid.2013.08.015" target="_blank" >10.1016/j.meegid.2013.08.015</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Molecular characterization of the African orthobunyavirus Ilesha virus

Popis výsledku v původním jazyce

Ilesha virus is an arthropod-borne virus belonging to the genus Orthobunyavirus of the Bunyaviridae family. Ilesha virus has been isolated from humans in several African countries, mostly in relation with febrile illness and erythema, though there are reported cases of fatal meningoencephalitis and hemorrhagic fever. In the present study, we report the complete genomic sequence of all three Ilesha virus segments (S, M, L) and characterize the open reading frames. The nucleoprotein encoded by segment S contains 59 conserved orthobunyavirus amino acids putatively critical for protein function. For the polyprotein encoded by segment M, potential proteolytic cleavage sites and N-glycosylation sites as well as conserved cysteines are described in referenceto other orthobunyaviruses. Within the C terminal glycoprotein Gc a putative fusion peptide could be localized. In the RNA-dependent RNA polymerase encoded by segment L, all strictly conserved amino acids within the four conserved regions

Název v anglickém jazyce

Molecular characterization of the African orthobunyavirus Ilesha virus

Popis výsledku anglicky

Ilesha virus is an arthropod-borne virus belonging to the genus Orthobunyavirus of the Bunyaviridae family. Ilesha virus has been isolated from humans in several African countries, mostly in relation with febrile illness and erythema, though there are reported cases of fatal meningoencephalitis and hemorrhagic fever. In the present study, we report the complete genomic sequence of all three Ilesha virus segments (S, M, L) and characterize the open reading frames. The nucleoprotein encoded by segment S contains 59 conserved orthobunyavirus amino acids putatively critical for protein function. For the polyprotein encoded by segment M, potential proteolytic cleavage sites and N-glycosylation sites as well as conserved cysteines are described in referenceto other orthobunyaviruses. Within the C terminal glycoprotein Gc a putative fusion peptide could be localized. In the RNA-dependent RNA polymerase encoded by segment L, all strictly conserved amino acids within the four conserved regions

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EE - Mikrobiologie, virologie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Infection, Genetics and Evolution

ISSN

1567-1348

e-ISSN

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Svazek periodika

20

Číslo periodika v rámci svazku

DEC 2013

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

7

Strana od-do

124-130

Kód UT WoS článku

000327701200017

EID výsledku v databázi Scopus

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