Analysis of biomarkers in a Czech population exposed to heavy air pollution. Part II. Chromosomal aberrations and oxidative stress
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F13%3A00425641" target="_blank" >RIV/60077344:_____/13:00425641 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/68378041:_____/13:00384434
Výsledek na webu
<a href="http://dx.doi.org/10.1093/mutage/ges058" target="_blank" >http://dx.doi.org/10.1093/mutage/ges058</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1093/mutage/ges058" target="_blank" >10.1093/mutage/ges058</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Analysis of biomarkers in a Czech population exposed to heavy air pollution. Part II. Chromosomal aberrations and oxidative stress
Popis výsledku v původním jazyce
The study indentified the effect of exposure to benzo[a]pyrene, particulate matter (PM2.5) and benzene on oxidative stress markers (8-oxodG, 15-F2t-IsoP and protein carbonyls) and cytogenetic parameters (stable and unstable chromosomal aberrations). Thesamples were collected from subjects from the Ostrava region and Prague in three seasons (winter 2009, summer 2009, and winter 2010). Despite several fold higher concentrations of air pollutants in the Ostrava region, the levels of stable aberrations were mostly comparable in both locations. The frequency of unstable aberrations was unexpectedly significantly lower in the Ostrava region subjects in both seasons of 2009. Urinary excretion of 8-oxodG did not differ between locations in either season. Lipid peroxidation measured as levels of 15-F2t-IsoP in blood plasma was elevated in the Ostrava subjects sampled in 2009. Protein oxidation was higher in Prague samples collected in summer 2009. Multivariate analyses showed a negative associ
Název v anglickém jazyce
Analysis of biomarkers in a Czech population exposed to heavy air pollution. Part II. Chromosomal aberrations and oxidative stress
Popis výsledku anglicky
The study indentified the effect of exposure to benzo[a]pyrene, particulate matter (PM2.5) and benzene on oxidative stress markers (8-oxodG, 15-F2t-IsoP and protein carbonyls) and cytogenetic parameters (stable and unstable chromosomal aberrations). Thesamples were collected from subjects from the Ostrava region and Prague in three seasons (winter 2009, summer 2009, and winter 2010). Despite several fold higher concentrations of air pollutants in the Ostrava region, the levels of stable aberrations were mostly comparable in both locations. The frequency of unstable aberrations was unexpectedly significantly lower in the Ostrava region subjects in both seasons of 2009. Urinary excretion of 8-oxodG did not differ between locations in either season. Lipid peroxidation measured as levels of 15-F2t-IsoP in blood plasma was elevated in the Ostrava subjects sampled in 2009. Protein oxidation was higher in Prague samples collected in summer 2009. Multivariate analyses showed a negative associ
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
EB - Genetika a molekulární biologie
OECD FORD obor
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Návaznosti výsledku
Projekt
Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.
Návaznosti
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2013
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Mutagenesis
ISSN
0267-8357
e-ISSN
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Svazek periodika
28
Číslo periodika v rámci svazku
1
Stát vydavatele periodika
GB - Spojené království Velké Británie a Severního Irska
Počet stran výsledku
10
Strana od-do
97-106
Kód UT WoS článku
000312888900012
EID výsledku v databázi Scopus
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