Expression of XRCC5 in peripheral blood lymphocytes is upregulated in subjects from a heavily polluted region in the Czech Republic

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F11%3A00365854" target="_blank" >RIV/68378041:_____/11:00365854 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.mrfmmm.2011.06.001" target="_blank" >http://dx.doi.org/10.1016/j.mrfmmm.2011.06.001</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.mrfmmm.2011.06.001" target="_blank" >10.1016/j.mrfmmm.2011.06.001</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Expression of XRCC5 in peripheral blood lymphocytes is upregulated in subjects from a heavily polluted region in the Czech Republic

Popis výsledku v původním jazyce

The levels of oxidative stress markers [8-oxodG, 15-F2t-IsoP, protein carbonyls] and cytogenetic parameters [FG/100, %AB.C., and (ace)] in subjects living in Prague (N=64) and in the heavily polluted Ostrava region (N=75) were investigated. Despite the fact, that the levels of air pollutants were significantly higher in Ostrava vs. Prague, neither differences in biomarkers of oxidative stress or in cytogenetic parameters between these two locations were found. Subjects living in Ostrava has increased odds of having above-median levels of XRCC5 expression. Above-median levels of 8-oxodG were associated with decreased levels of vitamin C and E, which were elevated in subjects from Ostrava. It may be concluded, that air pollution by c-PAHs affects XRCC5 gene expression, which probably protects subjects from Ostrava against the induction of a higher frequency of translocations, and elevated vitamin C and E levels decrease the levels of 8-oxodG.

Název v anglickém jazyce

Expression of XRCC5 in peripheral blood lymphocytes is upregulated in subjects from a heavily polluted region in the Czech Republic

Popis výsledku anglicky

The levels of oxidative stress markers [8-oxodG, 15-F2t-IsoP, protein carbonyls] and cytogenetic parameters [FG/100, %AB.C., and (ace)] in subjects living in Prague (N=64) and in the heavily polluted Ostrava region (N=75) were investigated. Despite the fact, that the levels of air pollutants were significantly higher in Ostrava vs. Prague, neither differences in biomarkers of oxidative stress or in cytogenetic parameters between these two locations were found. Subjects living in Ostrava has increased odds of having above-median levels of XRCC5 expression. Above-median levels of 8-oxodG were associated with decreased levels of vitamin C and E, which were elevated in subjects from Ostrava. It may be concluded, that air pollution by c-PAHs affects XRCC5 gene expression, which probably protects subjects from Ostrava against the induction of a higher frequency of translocations, and elevated vitamin C and E levels decrease the levels of 8-oxodG.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

DN - Vliv životního prostředí na zdraví

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2011

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

ISSN

0027-5107

e-ISSN

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Svazek periodika

713

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

7

Strana od-do

76-82

Kód UT WoS článku

000293930400009

EID výsledku v databázi Scopus

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