Analysis of biomarkers in a Czech population exposed to heavy air pollution. Part I. Bulky DNA adducts

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F13%3A00384430" target="_blank" >RIV/68378041:_____/13:00384430 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1093/mutage/ges057" target="_blank" >http://dx.doi.org/10.1093/mutage/ges057</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1093/mutage/ges057" target="_blank" >10.1093/mutage/ges057</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Analysis of biomarkers in a Czech population exposed to heavy air pollution. Part I. Bulky DNA adducts

Popis výsledku v původním jazyce

The impact of air pollution on the subjects living in a heavily polluted Ostrava region and in the relatively clean capital city of Prague was investigated. The study was conducted in three sampling periods (winter 2009, summer 2009, winter 2010) differing in the concentrations of major air pollutants. Concentrations of studied air pollutants (benzo[a]pyrene, benzene) were significantly higher in the Ostrava region in all sampling periods. Despite this fact the levels of bulky DNA adducts in peripheralblood lymphocytes were significantly elevated in the Ostrava subjects only in winter 2009. During the other two sampling periods, the levels of bulky DNA adducts were higher in the Prague subjects. Multivariate analyses revealed that exposure to B[a]P and particulate matter < 2.5 ?m affected bulky DNA adduct levels in the Ostrava subjects, but not in subjects from Prague.

Název v anglickém jazyce

Analysis of biomarkers in a Czech population exposed to heavy air pollution. Part I. Bulky DNA adducts

Popis výsledku anglicky

The impact of air pollution on the subjects living in a heavily polluted Ostrava region and in the relatively clean capital city of Prague was investigated. The study was conducted in three sampling periods (winter 2009, summer 2009, winter 2010) differing in the concentrations of major air pollutants. Concentrations of studied air pollutants (benzo[a]pyrene, benzene) were significantly higher in the Ostrava region in all sampling periods. Despite this fact the levels of bulky DNA adducts in peripheralblood lymphocytes were significantly elevated in the Ostrava subjects only in winter 2009. During the other two sampling periods, the levels of bulky DNA adducts were higher in the Prague subjects. Multivariate analyses revealed that exposure to B[a]P and particulate matter < 2.5 ?m affected bulky DNA adduct levels in the Ostrava subjects, but not in subjects from Prague.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

DN - Vliv životního prostředí na zdraví

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Mutagenesis

ISSN

0267-8357

e-ISSN

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Svazek periodika

28

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

7

Strana od-do

89-95

Kód UT WoS článku

000312888900011

EID výsledku v databázi Scopus

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