sRNAbench: profiling of small RNAs and its sequence variants in single or multi-species high-throughput experiments

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F14%3A00439419" target="_blank" >RIV/60077344:_____/14:00439419 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.2478/mngs-2014-0001" target="_blank" >http://dx.doi.org/10.2478/mngs-2014-0001</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.2478/mngs-2014-0001" target="_blank" >10.2478/mngs-2014-0001</a>

Jazyk výsledku

angličtina

Název v původním jazyce

sRNAbench: profiling of small RNAs and its sequence variants in single or multi-species high-throughput experiments

Popis výsledku v původním jazyce

MicroRNAs and other small RNAs are known to play important functions in gene regulation. Over the last years, it became also apparent that many virus genomes encode microRNAs and that those strongly interact with the host transcriptome. Important functions include the evasion of the immune response and the regulation of the switch to lytic infection. Since the advent of deep sequencing protocols for small RNAs, expression profiles can be routinely determined. However, currently the tools developed for the data analysis of small RNA deep sequencing experiments are limited to the analysis of only one species at a time. In order to facilitate the analysis of experimental setups that include genetic material from several species, we developed sRNAbench. Itmaintains the main features implemented in its predecessor program, miRanalyzer, and includes new functionalities such as full isomiR support including statistical test on differential frequency, improved prediction of novel microRNAs, e

Název v anglickém jazyce

sRNAbench: profiling of small RNAs and its sequence variants in single or multi-species high-throughput experiments

Popis výsledku anglicky

MicroRNAs and other small RNAs are known to play important functions in gene regulation. Over the last years, it became also apparent that many virus genomes encode microRNAs and that those strongly interact with the host transcriptome. Important functions include the evasion of the immune response and the regulation of the switch to lytic infection. Since the advent of deep sequencing protocols for small RNAs, expression profiles can be routinely determined. However, currently the tools developed for the data analysis of small RNA deep sequencing experiments are limited to the analysis of only one species at a time. In order to facilitate the analysis of experimental setups that include genetic material from several species, we developed sRNAbench. Itmaintains the main features implemented in its predecessor program, miRanalyzer, and includes new functionalities such as full isomiR support including statistical test on differential frequency, improved prediction of novel microRNAs, e

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EB - Genetika a molekulární biologie

OECD FORD obor

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Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Methods in Next Generation Sequencing

ISSN

2084-7173

e-ISSN

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Svazek periodika

1

Číslo periodika v rámci svazku

SEP 30 2014

Stát vydavatele periodika

PL - Polská republika

Počet stran výsledku

11

Strana od-do

21-31

Kód UT WoS článku

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EID výsledku v databázi Scopus

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