Extracellular small RNAs and their transfer between species and kingdoms

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F19%3A00523495" target="_blank" >RIV/68378050:_____/19:00523495 - isvavai.cz</a>

Výsledek na webu

—

DOI - Digital Object Identifier

—

Jazyk výsledku

angličtina

Název v původním jazyce

Extracellular small RNAs and their transfer between species and kingdoms

Popis výsledku v původním jazyce

RNA silencing is a common term for mechanisms where small RNAs guide repression of other RNAs (mRNAs, retrotransposon RNAs, viral RNAs) in a sequence-specific manner. RNA silencing exists among eukaryotic organisms where the core mechanisms evolved into many variants with different biological functions. The two most common RNA silencing pathways are microRNA (miRNA) and RNA interference (RNAi). While the miRNA pathway serves for negative regulation of endogenous genes, RNAi pathway usually functions as a form of protection against parasitic sequences although it also target endogenous genes in some cases. Notably, RNA silencing does not operate in a cell-autonomous manner. In a number of cases, small RNAs were detected in extracellular environment and were observed to pass through cells and oven be transferred between organisms. This review provides an overview “mobile” small RNAs, with a particular focus on miRNAs and short interfering RNAs (siRNA) of the RNAi pathways, which exert their effects in different species than they originate from.

Název v anglickém jazyce

Extracellular small RNAs and their transfer between species and kingdoms

Popis výsledku anglicky

RNA silencing is a common term for mechanisms where small RNAs guide repression of other RNAs (mRNAs, retrotransposon RNAs, viral RNAs) in a sequence-specific manner. RNA silencing exists among eukaryotic organisms where the core mechanisms evolved into many variants with different biological functions. The two most common RNA silencing pathways are microRNA (miRNA) and RNA interference (RNAi). While the miRNA pathway serves for negative regulation of endogenous genes, RNAi pathway usually functions as a form of protection against parasitic sequences although it also target endogenous genes in some cases. Notably, RNA silencing does not operate in a cell-autonomous manner. In a number of cases, small RNAs were detected in extracellular environment and were observed to pass through cells and oven be transferred between organisms. This review provides an overview “mobile” small RNAs, with a particular focus on miRNAs and short interfering RNAs (siRNA) of the RNAi pathways, which exert their effects in different species than they originate from.

Druh

C - Kapitola v odborné knize

CEP obor

—

OECD FORD obor

10602 - Biology (theoretical, mathematical, thermal, cryobiology, biological rhythm), Evolutionary biology

Projekt

<a href="/cs/project/LO1220" target="_blank" >LO1220: CZ-OPENSCREEN: Národní infrastruktura chemické biologie</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

Introduction to RNAi and miRNA pathways

ISBN

978-80-246-4372-4

Počet stran výsledku

8

Strana od-do

1-339

Počet stran knihy

339

Název nakladatele

Karolinum

Místo vydání

Praha

Kód UT WoS kapitoly

—