RNAi and miRNA pathways in nematodes

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F19%3A00523491" target="_blank" >RIV/68378050:_____/19:00523491 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

RNAi and miRNA pathways in nematodes

Popis výsledku v původním jazyce

RNA silencing denotes sequence-specific repression mediated by small RNAs. In metazoa, there are two mechanistically closely related pathways: RNA interference (RNAi) and microRNA (miRNA) pathway. The miRNA pathway serves to regulate endogenous protein-coding gene expression and has been implicated in many biological processes. RNAi generally serves as a form of innate immunity targeting viruses and mobile elements. This review is summarizing information about RNAi and miRNA pathways in the phylum Nematoda. Research on miRNA and RNAi pathway in the phylum Nematoda has been primarily using Caenorhabditis elegans model system and related species. In fact, miRNA and RNAi pathways were both discovered in this model system. Studies in Caenorhabditis elegans revealed highly complex organization of small RNA pathways despite there is just a single Dicer gene. The complexity of small RNA pathways in Caenorhabditis elegans stems from a large number of Argonaute proteins and three RNA-dependent RNA polymerases, which establish an intricate system of primary and secondary small RNAs with different biological functions in the cytoplasm and nucleus. This review focuses on the miRNA pathway and pathways initiated by long dsRNA. The first part introduces the key molecular players of RNA silencing in nematodes. The second summarizes miRNA and dsRNA-induced mechanisms, in this case RNAi (exogenous = exo-RNAi and endogenous = endo-RNAi) and adenosine deamination (nematodes do not have the interferon system like vertebrate groups).

Název v anglickém jazyce

RNAi and miRNA pathways in nematodes

Popis výsledku anglicky

RNA silencing denotes sequence-specific repression mediated by small RNAs. In metazoa, there are two mechanistically closely related pathways: RNA interference (RNAi) and microRNA (miRNA) pathway. The miRNA pathway serves to regulate endogenous protein-coding gene expression and has been implicated in many biological processes. RNAi generally serves as a form of innate immunity targeting viruses and mobile elements. This review is summarizing information about RNAi and miRNA pathways in the phylum Nematoda. Research on miRNA and RNAi pathway in the phylum Nematoda has been primarily using Caenorhabditis elegans model system and related species. In fact, miRNA and RNAi pathways were both discovered in this model system. Studies in Caenorhabditis elegans revealed highly complex organization of small RNA pathways despite there is just a single Dicer gene. The complexity of small RNA pathways in Caenorhabditis elegans stems from a large number of Argonaute proteins and three RNA-dependent RNA polymerases, which establish an intricate system of primary and secondary small RNAs with different biological functions in the cytoplasm and nucleus. This review focuses on the miRNA pathway and pathways initiated by long dsRNA. The first part introduces the key molecular players of RNA silencing in nematodes. The second summarizes miRNA and dsRNA-induced mechanisms, in this case RNAi (exogenous = exo-RNAi and endogenous = endo-RNAi) and adenosine deamination (nematodes do not have the interferon system like vertebrate groups).

Druh

C - Kapitola v odborné knize

CEP obor

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OECD FORD obor

10602 - Biology (theoretical, mathematical, thermal, cryobiology, biological rhythm), Evolutionary biology

Projekt

<a href="/cs/project/LO1220" target="_blank" >LO1220: CZ-OPENSCREEN: Národní infrastruktura chemické biologie</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

Introduction to RNAi and miRNA pathways

ISBN

978-80-246-4372-4

Počet stran výsledku

26

Strana od-do

1-339

Počet stran knihy

339

Název nakladatele

Karolinum

Místo vydání

Praha

Kód UT WoS kapitoly

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