RNAi and miRNA pathways in birds

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F19%3A00523487" target="_blank" >RIV/68378050:_____/19:00523487 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

RNAi and miRNA pathways in birds

Popis výsledku v původním jazyce

RNA silencing denotes sequence-specific repression mediated by small RNAs. In vertebrates, there are two closely related pathways, which share several protein factors: RNA interference (RNAi) and microRNA (miRNA) pathway. The miRNA pathway serves to regulate endogenous protein-coding gene expression and has been implicated in many biological processes. RNAi generally serves as a form of innate immunity targeting viruses and mobile elements. This work reviews miRNA and RNAi pathways in birds. Although the available literature on RNA silencing in birds is very limited, many features can be deduced from the genomic data in the public domain. miRNA, RNAi and other dsRNA-responding pathways in birds appear very much like those in mammals, important bird-specific features of RNA silencing pathways are yet to be identified. The miRNA pathway is likely the dominant small RNA pathway while the existence and functionality of endogenous RNAi remains unclear. Some variations may be present in the main bird antiviral interferon system.

Název v anglickém jazyce

RNAi and miRNA pathways in birds

Popis výsledku anglicky

RNA silencing denotes sequence-specific repression mediated by small RNAs. In vertebrates, there are two closely related pathways, which share several protein factors: RNA interference (RNAi) and microRNA (miRNA) pathway. The miRNA pathway serves to regulate endogenous protein-coding gene expression and has been implicated in many biological processes. RNAi generally serves as a form of innate immunity targeting viruses and mobile elements. This work reviews miRNA and RNAi pathways in birds. Although the available literature on RNA silencing in birds is very limited, many features can be deduced from the genomic data in the public domain. miRNA, RNAi and other dsRNA-responding pathways in birds appear very much like those in mammals, important bird-specific features of RNA silencing pathways are yet to be identified. The miRNA pathway is likely the dominant small RNA pathway while the existence and functionality of endogenous RNAi remains unclear. Some variations may be present in the main bird antiviral interferon system.

Druh

C - Kapitola v odborné knize

CEP obor

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OECD FORD obor

10602 - Biology (theoretical, mathematical, thermal, cryobiology, biological rhythm), Evolutionary biology

Projekt

<a href="/cs/project/LO1220" target="_blank" >LO1220: CZ-OPENSCREEN: Národní infrastruktura chemické biologie</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

Introduction to RNAi and miRNA pathways

ISBN

978-80-246-4372-4

Počet stran výsledku

14

Strana od-do

1-339

Počet stran knihy

339

Název nakladatele

Karolinum

Místo vydání

Praha

Kód UT WoS kapitoly

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