RNAi and miRNA pathways in arthropods

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F19%3A00523489" target="_blank" >RIV/68378050:_____/19:00523489 - isvavai.cz</a>

Výsledek na webu

—

DOI - Digital Object Identifier

—

Jazyk výsledku

angličtina

Název v původním jazyce

RNAi and miRNA pathways in arthropods

Popis výsledku v původním jazyce

RNA silencing denotes sequence-specific repression mediated by small RNAs. In vertebrates, there are two closely related pathways, which share several protein factors: RNA interference (RNAi) and microRNA (miRNA) pathway. The miRNA pathway serves to regulate endogenous protein-coding gene expression and has been implicated in many biological processes. RNAi generally serves as a form of innate immunity targeting viruses and mobile elements. While Arthropoda are an extremely large and diverse phylum, research on microRNA (miRNA) and RNA interference (RNAi) pathway in this phylum primarily used the Drosophila melanogaster model system and related species. Notably, both pathways are genetically separated, they utilize dedicated Dicer proteins to produce miRNAs and small interfering RNAs (siRNAs), which are sorted onto different Argonaute effector proteins. This review focuses on the miRNA pathway and pathways initiated by long dsRNA in arthropods. The first part introduces the key molecular players of RNA silencing. The second discussed biological roles of miRNA and dsRNA-induced pathways in Arthropods.

Název v anglickém jazyce

RNAi and miRNA pathways in arthropods

Popis výsledku anglicky

RNA silencing denotes sequence-specific repression mediated by small RNAs. In vertebrates, there are two closely related pathways, which share several protein factors: RNA interference (RNAi) and microRNA (miRNA) pathway. The miRNA pathway serves to regulate endogenous protein-coding gene expression and has been implicated in many biological processes. RNAi generally serves as a form of innate immunity targeting viruses and mobile elements. While Arthropoda are an extremely large and diverse phylum, research on microRNA (miRNA) and RNA interference (RNAi) pathway in this phylum primarily used the Drosophila melanogaster model system and related species. Notably, both pathways are genetically separated, they utilize dedicated Dicer proteins to produce miRNAs and small interfering RNAs (siRNAs), which are sorted onto different Argonaute effector proteins. This review focuses on the miRNA pathway and pathways initiated by long dsRNA in arthropods. The first part introduces the key molecular players of RNA silencing. The second discussed biological roles of miRNA and dsRNA-induced pathways in Arthropods.

Druh

C - Kapitola v odborné knize

CEP obor

—

OECD FORD obor

10602 - Biology (theoretical, mathematical, thermal, cryobiology, biological rhythm), Evolutionary biology

Projekt

<a href="/cs/project/LO1220" target="_blank" >LO1220: CZ-OPENSCREEN: Národní infrastruktura chemické biologie</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

Introduction to RNAi and miRNA pathways

ISBN

978-80-246-4372-4

Počet stran výsledku

34

Strana od-do

1-339

Počet stran knihy

339

Název nakladatele

Karolinum

Místo vydání

Praha

Kód UT WoS kapitoly

—