Mutation in the Drosophila melanogaster adenosine receptor gene selectively decreases the mosaic hyperplastic epithelial outgrowth rates in wts or dco heterozygous flies

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F15%3A00438115" target="_blank" >RIV/60077344:_____/15:00438115 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/60076658:12310/15:43890324

Výsledek na webu

<a href="http://link.springer.com/article/10.1007%2Fs11302-014-9435-2" target="_blank" >http://link.springer.com/article/10.1007%2Fs11302-014-9435-2</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s11302-014-9435-2" target="_blank" >10.1007/s11302-014-9435-2</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Mutation in the Drosophila melanogaster adenosine receptor gene selectively decreases the mosaic hyperplastic epithelial outgrowth rates in wts or dco heterozygous flies

Popis výsledku v původním jazyce

Adenosine (Ado) is a purine nucleoside that modulates many physiological processes in the body. It plays a prominent role as a paracrine signal of metabolic imbalance within tissues and serves as a signaling mechanism to coordinate tissue activity. Ado exerts a broad range of cytoprotective, growth-promoting, and immunosuppressive effects and was observed at a high concentration in a number of human tumors, it was therefore suggested to be an important factor regulating tumor growth. We developed a method for the measurement of the Ado effect on tumor growth in/Drosophila melanogaster/using the modification of somatic mutation and recombination test (SMART). In this report, we examined the effect of three/Drosophila/genes involved in Ado signaling on the incidence of somatic mosaic clones, including adenosine receptor (/AdoR/), adenosine transporter (/Ent2/), and adenosine deaminase/Adgf-A/. We show that genetic manipulations with these genes do not affect control clones, but cause dra

Název v anglickém jazyce

Mutation in the Drosophila melanogaster adenosine receptor gene selectively decreases the mosaic hyperplastic epithelial outgrowth rates in wts or dco heterozygous flies

Popis výsledku anglicky

Adenosine (Ado) is a purine nucleoside that modulates many physiological processes in the body. It plays a prominent role as a paracrine signal of metabolic imbalance within tissues and serves as a signaling mechanism to coordinate tissue activity. Ado exerts a broad range of cytoprotective, growth-promoting, and immunosuppressive effects and was observed at a high concentration in a number of human tumors, it was therefore suggested to be an important factor regulating tumor growth. We developed a method for the measurement of the Ado effect on tumor growth in/Drosophila melanogaster/using the modification of somatic mutation and recombination test (SMART). In this report, we examined the effect of three/Drosophila/genes involved in Ado signaling on the incidence of somatic mosaic clones, including adenosine receptor (/AdoR/), adenosine transporter (/Ent2/), and adenosine deaminase/Adgf-A/. We show that genetic manipulations with these genes do not affect control clones, but cause dra

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EB - Genetika a molekulární biologie

OECD FORD obor

—

Projekt

<a href="/cs/project/GA14-27816S" target="_blank" >GA14-27816S: Funkce adenozinové signalizace v organismu</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Purinergic Signalling

ISSN

1573-9538

e-ISSN

—

Svazek periodika

11

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

11

Strana od-do

95-105

Kód UT WoS článku

000350883100006

EID výsledku v databázi Scopus

2-s2.0-84925535445