The course of infection caused by Encephalitozoon cuniculi genotype III in immunocompetent and immunodeficient mice

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F17%3A00479556" target="_blank" >RIV/60077344:_____/17:00479556 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/60076658:12220/17:43896919

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.exppara.2017.09.022" target="_blank" >http://dx.doi.org/10.1016/j.exppara.2017.09.022</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.exppara.2017.09.022" target="_blank" >10.1016/j.exppara.2017.09.022</a>

Jazyk výsledku

angličtina

Název v původním jazyce

The course of infection caused by Encephalitozoon cuniculi genotype III in immunocompetent and immunodeficient mice

Popis výsledku v původním jazyce

Encephalitozoon cuniculi is probably the most common microsporidia which infects a wide range of vertebrates, including human. So far, four genotypes of this parasite have been identified based on the rRNA internal transcribed spacer variations. The course of infection caused by E. cuniculi III had very massive onset in immunocompetent host characterized by the presence of this parasite in all organs and tissues within one week after peroral infection. Encephalitozoonosis caused by E. cuniculi III had very progressive spreading into all organs within first week post inoculation in immunocompromised SCID mice and led to the death of the host. The experimental treatment with albendazole of immunocompetent BALB/c mice infected with E. cuniculi III have shown very weak effect. Our findings clearly showed that the different course of infection and response to treatment depends not only on the immunological status of the host, but also on the genotype of microsporidia. It could be very important especially for individuals under chemotherapy and transplant recipients of organs originating from infected donors.

Název v anglickém jazyce

The course of infection caused by Encephalitozoon cuniculi genotype III in immunocompetent and immunodeficient mice

Popis výsledku anglicky

Encephalitozoon cuniculi is probably the most common microsporidia which infects a wide range of vertebrates, including human. So far, four genotypes of this parasite have been identified based on the rRNA internal transcribed spacer variations. The course of infection caused by E. cuniculi III had very massive onset in immunocompetent host characterized by the presence of this parasite in all organs and tissues within one week after peroral infection. Encephalitozoonosis caused by E. cuniculi III had very progressive spreading into all organs within first week post inoculation in immunocompromised SCID mice and led to the death of the host. The experimental treatment with albendazole of immunocompetent BALB/c mice infected with E. cuniculi III have shown very weak effect. Our findings clearly showed that the different course of infection and response to treatment depends not only on the immunological status of the host, but also on the genotype of microsporidia. It could be very important especially for individuals under chemotherapy and transplant recipients of organs originating from infected donors.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30303 - Infectious Diseases

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Experimental Parasitology

ISSN

0014-4894

e-ISSN

—

Svazek periodika

182

Číslo periodika v rámci svazku

November

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

6

Strana od-do

16-21

Kód UT WoS článku

000413887600003

EID výsledku v databázi Scopus

2-s2.0-85029673120