Tick Saliva and Microbial Effector Molecules: Two Sides of the Same Coin

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F17%3A00485348" target="_blank" >RIV/60077344:_____/17:00485348 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1016/B978-0-12-805360-7.00010-1" target="_blank" >http://dx.doi.org/10.1016/B978-0-12-805360-7.00010-1</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/B978-0-12-805360-7.00010-1" target="_blank" >10.1016/B978-0-12-805360-7.00010-1</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Tick Saliva and Microbial Effector Molecules: Two Sides of the Same Coin

Popis výsledku v původním jazyce

Host immunity can be divided into two branches: innate and adaptive. The Toll-like and Nod-like receptor pathways are the two best characterized innate signaling cascades. Parasitic organisms have evolved a wide range of methods to invade and persist on and/or within hosts. The main crux of this life strategy hinges on the ability to evade or interrupt the host immune response. In the context of microbial pathogenesis, secreted effector molecules are an immunomodulatory staple. Similarly, ectoparasitic organisms, such as a tick, use salivary molecules to modulate immune processes that favor blood feeding and survival. In this chapter, we will discuss the commonalities between the immunomodulatory properties of tick saliva and microbial-derived effector molecules in the context of Nod-like receptor signaling. Given the extensive body of literature surrounding microbial effectors, we offer the opinion that this can be used to guide discovery and molecular characterization of tick salivary molecules.

Název v anglickém jazyce

Tick Saliva and Microbial Effector Molecules: Two Sides of the Same Coin

Popis výsledku anglicky

Host immunity can be divided into two branches: innate and adaptive. The Toll-like and Nod-like receptor pathways are the two best characterized innate signaling cascades. Parasitic organisms have evolved a wide range of methods to invade and persist on and/or within hosts. The main crux of this life strategy hinges on the ability to evade or interrupt the host immune response. In the context of microbial pathogenesis, secreted effector molecules are an immunomodulatory staple. Similarly, ectoparasitic organisms, such as a tick, use salivary molecules to modulate immune processes that favor blood feeding and survival. In this chapter, we will discuss the commonalities between the immunomodulatory properties of tick saliva and microbial-derived effector molecules in the context of Nod-like receptor signaling. Given the extensive body of literature surrounding microbial effectors, we offer the opinion that this can be used to guide discovery and molecular characterization of tick salivary molecules.

Druh

C - Kapitola v odborné knize

CEP obor

—

OECD FORD obor

10608 - Biochemistry and molecular biology

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

Arthropod Vector: Controller of Disease Transmission

ISBN

9780128053607

Počet stran výsledku

26

Strana od-do

169-194

Počet stran knihy

315

Název nakladatele

Elsevier

Místo vydání

UK

Kód UT WoS kapitoly

000411819200011