Effect of blood type on anti-alpha-Gal immunity and the incidence of infectious diseases

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F17%3A00507415" target="_blank" >RIV/60077344:_____/17:00507415 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/60076658:12310/17:43895742

Výsledek na webu

<a href="https://www.nature.com/articles/emm2016164" target="_blank" >https://www.nature.com/articles/emm2016164</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/emm.2016.164" target="_blank" >10.1038/emm.2016.164</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Effect of blood type on anti-alpha-Gal immunity and the incidence of infectious diseases

Popis výsledku v původním jazyce

The identification of factors affecting the susceptibility to infectious diseases is essential toward reducing their burden on the human population. The ABO blood type correlates with susceptibility to malaria and other infectious diseases. Due to the structural similarity between blood antigen B and Gal alpha 1-3Gal beta 1-(3)4GlcNAc-R (alpha-Gal), we hypothesized that self-tolerance to antigen B affects the immune response to alpha-Gal, which in turn affects the susceptibility to infectious diseases caused by pathogens carrying alpha-Gal on their surface. Here we found that the incidence of malaria and tuberculosis, caused by pathogens with alpha-Gal on their surface, positively correlates with the frequency of blood type B in endemic regions. However, the incidence of dengue fever, caused by a pathogen without alpha-Gal, was not related to the frequency of blood type B in these populations. Furthermore, the incidence of malaria and tuberculosis was negatively correlated with the anti-alpha-Gal antibody protective response. These results have implications for disease control and prevention.

Název v anglickém jazyce

Effect of blood type on anti-alpha-Gal immunity and the incidence of infectious diseases

Popis výsledku anglicky

The identification of factors affecting the susceptibility to infectious diseases is essential toward reducing their burden on the human population. The ABO blood type correlates with susceptibility to malaria and other infectious diseases. Due to the structural similarity between blood antigen B and Gal alpha 1-3Gal beta 1-(3)4GlcNAc-R (alpha-Gal), we hypothesized that self-tolerance to antigen B affects the immune response to alpha-Gal, which in turn affects the susceptibility to infectious diseases caused by pathogens carrying alpha-Gal on their surface. Here we found that the incidence of malaria and tuberculosis, caused by pathogens with alpha-Gal on their surface, positively correlates with the frequency of blood type B in endemic regions. However, the incidence of dengue fever, caused by a pathogen without alpha-Gal, was not related to the frequency of blood type B in these populations. Furthermore, the incidence of malaria and tuberculosis was negatively correlated with the anti-alpha-Gal antibody protective response. These results have implications for disease control and prevention.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10608 - Biochemistry and molecular biology

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Experimental and Molecular Medicine

ISSN

1226-3613

e-ISSN

—

Svazek periodika

49

Číslo periodika v rámci svazku

MAR 2017

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

7

Strana od-do

e301

Kód UT WoS článku

000397275000004

EID výsledku v databázi Scopus

2-s2.0-85020575383