The kinetochore and the origin of eukaryotic chromosome segregation

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F19%3A00519521" target="_blank" >RIV/60077344:_____/19:00519521 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.pnas.org/doi/full/10.1073/pnas.1908067116" target="_blank" >https://www.pnas.org/doi/full/10.1073/pnas.1908067116</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

The kinetochore and the origin of eukaryotic chromosome segregation

Popis výsledku v původním jazyce

All organisms must faithfully segregate their DNA during cell division to safeguard complete inheritance of the genome. In eukaryotes, mechanisms of cell and nuclear division are highly variable, and while these usually involve the use of a mitotic microtubule-based spindle and a kinetochore (KT) that physically links the chromatin and spindle, beyond this, the arrangement and manner in which mitosis is completed can adopt one of a vast number of disparate pathways (1, 2). Each of these pathways requires the participation of multiple cellular functions, including the nucleoskeleton, centromeres (chromatin-marked KT assembly sites), the nuclear envelope, and the nuclear pore complex (NPC), to achieve the ultimate goal of partitioning a complete genome to both daughter cells. Because the eukaryotic genome is contained on multiple DNA elements and is frequently diploid makes this task even more challenging. In PNAS, Tromer et al. (3) revisit the origin of a key component, the KT, using highly sensitive sequence and architectural search methods to provide a possible evolutionary history.

Název v anglickém jazyce

The kinetochore and the origin of eukaryotic chromosome segregation

Popis výsledku anglicky

All organisms must faithfully segregate their DNA during cell division to safeguard complete inheritance of the genome. In eukaryotes, mechanisms of cell and nuclear division are highly variable, and while these usually involve the use of a mitotic microtubule-based spindle and a kinetochore (KT) that physically links the chromatin and spindle, beyond this, the arrangement and manner in which mitosis is completed can adopt one of a vast number of disparate pathways (1, 2). Each of these pathways requires the participation of multiple cellular functions, including the nucleoskeleton, centromeres (chromatin-marked KT assembly sites), the nuclear envelope, and the nuclear pore complex (NPC), to achieve the ultimate goal of partitioning a complete genome to both daughter cells. Because the eukaryotic genome is contained on multiple DNA elements and is frequently diploid makes this task even more challenging. In PNAS, Tromer et al. (3) revisit the origin of a key component, the KT, using highly sensitive sequence and architectural search methods to provide a possible evolutionary history.

Druh

O - Ostatní výsledky

CEP obor

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OECD FORD obor

10606 - Microbiology

Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů