More than just a focus: The chromatin response to DNA damage and its role in genome integrity maintenance

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F11%3A10225009" target="_blank" >RIV/61989592:15110/11:10225009 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

More than just a focus: The chromatin response to DNA damage and its role in genome integrity maintenance

Popis výsledku v původním jazyce

Following the discovery in 1998 of gamma-H2AX, the first histone modification induced by DNA damage(1), interest in the changes to chromatin induced by DNA damage has exploded, and a vast amount of information has been generated. However, there has beena discrepancy between our rapidly advancing knowledge of how chromatin responds to DNA damage and the understanding of why cells mobilize large segments of chromatin to protect the genome against destabilizing effects posed by tiny DNA lesions. Recent research has provided insights into these issues and suggests that chromatin responses induced by DNA damage are not simply the accumulation of 'nuclear foci' but are mechanisms required to guard genome integrity.

Název v anglickém jazyce

More than just a focus: The chromatin response to DNA damage and its role in genome integrity maintenance

Popis výsledku anglicky

Following the discovery in 1998 of gamma-H2AX, the first histone modification induced by DNA damage(1), interest in the changes to chromatin induced by DNA damage has exploded, and a vast amount of information has been generated. However, there has beena discrepancy between our rapidly advancing knowledge of how chromatin responds to DNA damage and the understanding of why cells mobilize large segments of chromatin to protect the genome against destabilizing effects posed by tiny DNA lesions. Recent research has provided insights into these issues and suggests that chromatin responses induced by DNA damage are not simply the accumulation of 'nuclear foci' but are mechanisms required to guard genome integrity.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FD - Onkologie a hematologie

OECD FORD obor

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Projekt

<a href="/cs/project/ED0030%2F01%2F01" target="_blank" >ED0030/01/01: Biomedicína pro regionální rozvoj a lidské zdroje</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2011

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Nature Cell Biology (print)

ISSN

1465-7392

e-ISSN

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Svazek periodika

13

Číslo periodika v rámci svazku

10

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

9

Strana od-do

1161-1169

Kód UT WoS článku

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EID výsledku v databázi Scopus

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