Instability of aquaglyceroporin (AQP) 2 contributes to drug resistance inTrypanosoma brucei

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F20%3A00540068" target="_blank" >RIV/60077344:_____/20:00540068 - isvavai.cz</a>

Výsledek na webu

<a href="https://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0008458" target="_blank" >https://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0008458</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1371/journal.pntd.0008458" target="_blank" >10.1371/journal.pntd.0008458</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Instability of aquaglyceroporin (AQP) 2 contributes to drug resistance inTrypanosoma brucei

Popis výsledku v původním jazyce

Author summary Understanding mechanisms that make cells sensitive to xenobiotics (including drugs) is of great importance to both drug development and public health. For the latter, emergence of resistance is particularly important to monitor as well as to predict. Trypanosomes are a major global health burden and for several drugs resistance has emerged and is a considerable concern. Here we have examined the sensitivity to pentamidine, which is mainly mediated by an aquaglyceroporin, a surface channel. We find that the protein is highly sensitive to mutation, rendering the protein unstable, and rendering parasites resistant to pentamidine. As this also includes mutant forms recovered from patients where pentamidine treatment has failed, we suggest that the instability of aquaglyceroporin is an important contributor towards treatment failure.

Název v anglickém jazyce

Instability of aquaglyceroporin (AQP) 2 contributes to drug resistance inTrypanosoma brucei

Popis výsledku anglicky

Author summary Understanding mechanisms that make cells sensitive to xenobiotics (including drugs) is of great importance to both drug development and public health. For the latter, emergence of resistance is particularly important to monitor as well as to predict. Trypanosomes are a major global health burden and for several drugs resistance has emerged and is a considerable concern. Here we have examined the sensitivity to pentamidine, which is mainly mediated by an aquaglyceroporin, a surface channel. We find that the protein is highly sensitive to mutation, rendering the protein unstable, and rendering parasites resistant to pentamidine. As this also includes mutant forms recovered from patients where pentamidine treatment has failed, we suggest that the instability of aquaglyceroporin is an important contributor towards treatment failure.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30309 - Tropical medicine

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

PLoS Neglected Tropical Diseases

ISSN

1935-2735

e-ISSN

—

Svazek periodika

14

Číslo periodika v rámci svazku

7

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

26

Strana od-do

e0008458

Kód UT WoS článku

000552596700004

EID výsledku v databázi Scopus

2-s2.0-85089114743