Evolution, function and roles in drug sensitivity of trypanosome aquaglyceroporins

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F21%3A00554907" target="_blank" >RIV/60077344:_____/21:00554907 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.cambridge.org/core/journals/parasitology/article/evolution-function-and-roles-in-drug-sensitivity-of-trypanosome-aquaglyceroporins/34AF8BE79D25B40DB0EE1DC372A42EDA" target="_blank" >https://www.cambridge.org/core/journals/parasitology/article/evolution-function-and-roles-in-drug-sensitivity-of-trypanosome-aquaglyceroporins/34AF8BE79D25B40DB0EE1DC372A42EDA</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1017/S0031182021000354" target="_blank" >10.1017/S0031182021000354</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Evolution, function and roles in drug sensitivity of trypanosome aquaglyceroporins

Popis výsledku v původním jazyce

Aquaglyceroporins (AQPs) are membrane proteins that function in osmoregulation and the uptake of low molecular weight solutes, in particular glycerol and urea. The AQP family is highly conserved, with two major subfamilies having arisen very early in prokaryote evolution and retained by eukaryotes. A complex evolutionary history indicates multiple lineage-specific expansions, losses and not uncommonly a complete loss. Consequently, the AQP family is highly evolvable and has been associated with significant events in life on Earth. In the African trypanosomes, a role for the AQP2 paralogue, in sensitivity to two chemotherapeutic agents, pentamidine and melarsoprol, is well established, albeit with the mechanisms for cell entry and resistance unclear until very recently. Here, we discuss AQP evolution, structure and mechanisms by which AQPs impact drug sensitivity, suggesting that AQP2 stability is highly sensitive to mutation while serving as the major uptake pathway for pentamidine.

Název v anglickém jazyce

Evolution, function and roles in drug sensitivity of trypanosome aquaglyceroporins

Popis výsledku anglicky

Aquaglyceroporins (AQPs) are membrane proteins that function in osmoregulation and the uptake of low molecular weight solutes, in particular glycerol and urea. The AQP family is highly conserved, with two major subfamilies having arisen very early in prokaryote evolution and retained by eukaryotes. A complex evolutionary history indicates multiple lineage-specific expansions, losses and not uncommonly a complete loss. Consequently, the AQP family is highly evolvable and has been associated with significant events in life on Earth. In the African trypanosomes, a role for the AQP2 paralogue, in sensitivity to two chemotherapeutic agents, pentamidine and melarsoprol, is well established, albeit with the mechanisms for cell entry and resistance unclear until very recently. Here, we discuss AQP evolution, structure and mechanisms by which AQPs impact drug sensitivity, suggesting that AQP2 stability is highly sensitive to mutation while serving as the major uptake pathway for pentamidine.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30310 - Parasitology

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Parasitology

ISSN

0031-1820

e-ISSN

1469-8161

Svazek periodika

148

Číslo periodika v rámci svazku

10

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

6

Strana od-do

1137-1142

Kód UT WoS článku

000674635600005

EID výsledku v databázi Scopus

2-s2.0-85101227484